Frankly, I was shocked to hear Trump say something I believed

[intrepidity]

Which was that chloroquine (or derivative) may well be a promising treatment for coronavirus.

I do not understand the negativity here over it. And it preceded Trump's mentioning it.

I've read numerous research papers over the past few days that mention the drug and it's potential. It gives me hope.

ETA: a thread I posted a few weeks ago, which has links in it

https://www.democraticunderground.com/100213032549

[The Velveteen Ocelot]

1. The problem was that he made it sound like anybody could be treated with it right now,

but that's not true. I believe they are doing clinical trials.

[Kablooie]

3. Yes. Dr. Fauci last night said the evidence is anecdotal so far.

They will test it but it may not work and may have harmful effects.
Not something you want everyone to go out and try right away.

[In_The_Wind]

2. I did hear about it earlier this week. Let's hope it works.

[hlthe2b]

4. Chloroquine, a.k.a. chloroquine phosphate, related to Quinine-- present in tonic water.

will have to go through trials and an approval process before it can be used for COVID-19.

All we have is some case series data. Not to mention it is not clear there is a large supply available.

[The Velveteen Ocelot]

5. It's a little early in the year for gin and tonic, but maybe I should get started...

[hlthe2b]

8. It surely will give people ideas--sort of like every foodborne outbreak involving raw oysters...

the first question from the audience hearing the findings is "did you see a protective effect among those drinking alcohol?!" Every damned time (and no, there never is, whether Hepatitis A or Vibrio infections) LOL

[The Velveteen Ocelot]

11. I drink g&t every summer and I've never gotten malaria!

QED.

It might make me feel better, though. It's tempting to stay drunk for the next 18 months.

[hlthe2b]

13. Hah! Well, that proves it.

[woodsprite]

18. Wait! There's a "season" for Gin and Tonic? I had no idea! nt

[Demsrule86]

9. It does not have to go through trials...approved for other uses.

[hlthe2b]

12. It has to undergo efficacy trials for COVID-19. They will waive phase I safety.

Yes, physicians might try to use it off-label, but they would be walking on thin ice without more than a few case series data. If there were even one study completed somewhere, FDA could grant a "compassionate use" approval. There is not.

[uppityperson]

6. There is potential. He made it sound like it'd be out soon

Which it won't. He also made it sound like there are no adverse side effects or interactions. There are.

[intrepidity]

10. This drug has several things in it's favor

1) history -- well known safety and side effect profile
2) already approved as a human drug
3) old drug, no patents
4) manufacturing apparatus in place

In times of pandemic, those factors are invaluable, IMHO.

[uppityperson]

17. I agree. I'm waiting for a callback from a screening nurse right now

Wondering how many of the fragile people I work with won't survive.

[Demsrule86]

7. don't laugh, I bought quinine water and not the only one either. It can't hurt.

[intrepidity]

15. That may be going too far, but hey, who knows?

It apparently works by altering the pH of an area in the cell where the virus needs to carry out an enzymatic process in order to replicate.

Enzymes are notorious for being pH specific, meaning if the balance is off just a little, they can't work.

So, by simply knocking the pH off a little, chloroquine may effectively prevent--or limit--virus replication.

It makes sense.

[Hoyt]

14. Off-label use of drugs is quite common.

https://www.fda.gov/patients/learn-about-expanded-access-and-other-treatment-options/understanding-unapproved-use-approved-drugs-label

[intrepidity]

16. Exactly. nt

[magicarpet]

19. This is the problem with being a bullshit artist.....

.... no one is quite sure if you should ever be taken seriously because you word is of less value than dung. If this same person is a leader of a country - it can be dangerous for the people of that same country because they can not be trusted to telling the truth.


*~*~*~
Things we do know about COVID-19 from observing other countries who have also wrestled with this issue.

Medications that seem detrimental to COVID-19 sufferers:

* Ibuprofen - brand, Advil, Calodor, seem not beneficial to cut fever, use aspirin or doctor may order aspirin or acetaminophen, Tylenol but watch dose for liver damage.

* Steroid drugs, Prednisone seem detrimental to COVID-19 sufferers.

*~*~*~
~*~*~*
Medication proving to be beneficial to COVID-19 patients.

Prescription drugs already on the market but tested for other uses, doctor may cross proscribe, or FDA allow for compassionate use, IND.

An Investigational New Drug Application (IND) is a request for authorization from the Food and Drug Administration (FDA) to administer an investigational drug or biological product to humans.May 14, 2019

These have shown promising results for COVID-19 patients.

Anti retro virals - medications specific to HIV,
* Lopinavir
* Ritonavir
Show promising results for COVID-19 patients.

Out of Japan, by a pharma lab which is a subsidiary of Fuji Film,
* FAVIPIRAVIR, AKA AVIGAN Shows promising results for COVID-19 patients.

Out of France, Sandfi Labs, anti malarial,
* HYDROOXYCHLOROQUINE, AKA CHLOROQUINE, AKA PIAQUENIL, shows promise with COVID-19 patients, previously used for MERS & SARS.

If the above medication is used with *ZINC it boosts results.

* AZITHROMYCIN, anti malarial shows promise with COVID-19 patients.

* REMDESVIR, Specific to COVID-19 currently under drug study trial.

Antiviral technique known to FDA, nasal irrigation/flush with saline solution. If nasal cavities irrigated once a day viral count is significantly diminished.

AKA NEDDI POT, Google,
Google - nasal irrigation

DO NOT USE DIRECT TAP WATER, the water must be sterile bring to rolling boil then cool.

Saline solution formula,
I/2 teaspoon salt
Per 3 ounces of (sterile) water

* TAMIFLU, shows positive results for COVID-19 sufferers if administered within 24hrs of onset.

* VITAMIN D, in pill form, be known 20,000 of vitamin D is derived from 1/2hr of sun exposure.

* ZINC boosts the immune system.