Welcome to DU! The truly grassroots left-of-center political community where regular people, not algorithms, drive the discussions and set the standards. Join the community: Create a free account Support DU (and get rid of ads!): Become a Star Member Latest Breaking News General Discussion The DU Lounge All Forums Issue Forums Culture Forums Alliance Forums Region Forums Support Forums Help & Search

Yo_Mama_Been_Loggin

(107,996 posts)
Tue Apr 14, 2020, 02:07 PM Apr 2020

Head lice drug emerges as potential coronavirus treatment, studies show

From a century-old blood plasma therapy to an anti-malarial drug called hydroxychloroquine, the scientific community is exploring new ways to leverage existing treatments in the fight against the novel coronavirus.

-snip-

The development of ivermectin as an anti-parasitic treatment dates back to the 1970s and 1980s, first as a veterinary treatment for nematodes in cattle and later as a way to combat river blindness in humans. More recently, ivermectin is known for its topical use in treating head lice. Its use in treating those and other parasites has earned ivermectin a spot on the World Health Organization’s list of essential medicines.

But now, researchers are looking to the drug for broader use in killing off SARS-Cov-2, the virus that causes COVID-19 – and earlier this month, a team of scientists in Australia found just that in test tubes.

“We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours there was a really significant reduction in it,” said Dr. Kylie Wagstaff, the leader of the team from Melbourne’s Monash Biomedicine Discovery Institute.

The coronavirus is not a parasite, but experts suggest that the drug essentially treats it like one and blocks the viral RNA from invading healthy cells. Unable to enter the cell, the RNA is slowed from replicating, giving the patient's immune system more time to fight it off.

https://www.yahoo.com/gma/head-lice-drug-emerges-potential-coronavirus-treatment-studies-080301583--abc-news-topstories.html

Great. Here's another drug Trump will push before all tests are done.

24 replies = new reply since forum marked as read
Highlight: NoneDon't highlight anything 5 newestHighlight 5 most recent replies
Head lice drug emerges as potential coronavirus treatment, studies show (Original Post) Yo_Mama_Been_Loggin Apr 2020 OP
Sounds promising Loki Liesmith Apr 2020 #1
Big differences between in vitro and in vivo tests. MineralMan Apr 2020 #2
That was my thought as well Yo_Mama_Been_Loggin Apr 2020 #3
A lot of things disrupt viruses in a test tube. MineralMan Apr 2020 #4
Do not treat white feet! CountAllVotes Apr 2020 #10
pinups of melania's "modeling" pics have the same effect. msongs Apr 2020 #5
That's what I use for rosacea caused by demodex mites. Now the price is going up. Patterson Apr 2020 #6
Since when does a powerful horse worming drug work on COVID-19? CountAllVotes Apr 2020 #7
Great possibility, but hope no one drinks lice shampoo Hortensis Apr 2020 #8
and you better hope the child does not ingest it! CountAllVotes Apr 2020 #12
:) Well, when my children brought lice home Hortensis Apr 2020 #14
I used the word "ingest" CountAllVotes Apr 2020 #15
No, they were both poisoned too. Poison, then comb to Hortensis Apr 2020 #18
I had them too CountAllVotes Apr 2020 #19
:) You got the easy end. Upholstery, carpet, wardrobes, Hortensis Apr 2020 #21
This is the active ingredient in my dog's heart worm pills. mn9driver Apr 2020 #9
This whole pandemic stuff is a real head-scratcher. nt JustABozoOnThisBus Apr 2020 #11
Very true! CountAllVotes Apr 2020 #13
There is a small amount of clinical information in the article: Dem2 Apr 2020 #16
a small observational registry-based study CountAllVotes Apr 2020 #17
Yes, I agree Dem2 Apr 2020 #22
So this stuff works topically as well Horse with no Name Apr 2020 #20
"We won't get vaxed....Now if you'll excuse us, we're off to the farm store for animal medicine." LetMyPeopleVote Aug 2021 #23
Major study of Ivermectin, the anti-vaccine crowd's latest COVID drug, finds 'no effect whatsoever' LetMyPeopleVote Aug 2021 #24

MineralMan

(146,316 posts)
4. A lot of things disrupt viruses in a test tube.
Tue Apr 14, 2020, 02:15 PM
Apr 2020

Many of them are poisonous if injected into animals or humans.

This louse treatment is apparently OK in that regard, but there's no way to know if will will work in the human body to prevent the virus from getting into cells and reproducing. Only animal tests will provide a clue. I'm sure that's the next step.

CountAllVotes

(20,874 posts)
10. Do not treat white feet!
Tue Apr 14, 2020, 03:14 PM
Apr 2020

A variant of this crap poisoned and killed my cat in 2016.

She was blind and paralyzed to name just a few of her deadly symptoms!

And yes, she had white feet, hence the "Do not treat white feet". This is a genetic variant that causes animals (horses included) that will die if treated with this sh*t.
Dogs, esp. affected include Shelties, Dalmations, many small dogs, esp. thoroughbreds and many other breeds of both dogs and cats that have white feet!

After her death, I studied this extensively. I could not accept the cause of death listed as "unknown".

I still have that 3" thick file I complied during my research which went on for months after her death. She had 15 of the 20 symptoms of poisoning from SPINOSAD, but they ignored this FACT.

This same group of poisons is used on "organic" crops (orange, strawberries and lettuce to name just a few) and marijuana growers (the under-the-table ones) use this to control mites on marijuana crops, so please AVOID marijuana crops that are not tested for toxicity please!

It is aka SPINOSAD, the poison found in the flea killer known as "Comfortis".

Neurotoxic paralysis is what killed my cat, and wow, what a hell of a way to die! It was absolutely the most horrific thing I've ever seen in my life!

The drug companies know this but they continue to sell it anyway because it is all about money OF COURSE!

They really DO NOT CARE ABOUT U much less your now dead cat or dog!




CountAllVotes

(20,874 posts)
7. Since when does a powerful horse worming drug work on COVID-19?
Tue Apr 14, 2020, 02:42 PM
Apr 2020

Ivermectin is in a class of medications called anthelmintics. It treats strongyloidosis by killing the worms in the intestines. It treats onchocerciasis by killing the developing worms. Ivermectin does not kill the adult worms that cause onchocerciasis and therefore it will not cure this type of infection.

*******

The drug is called ivermectin and whilst it can do many things, one thing it can do is kill nerves. It appears by targeting a chloride channel (GABA) When it was given to a mouse strain called the MDR-1 mice, it killed them because of toxicity to the nerves. In Collie Dogs there were neurological problems and I once here a story of a human who was working at a Pot farm who got neurological problems. They were controlling pot mites with avermectin a close relative of ivermectin.

Whilst ivermectin has been used in millions of animals that have taken this drug as it is used to kill parasites like mites that live on the surface of people and even pinworms and it has also been used by millions of people to treat parasitic helminthic worm infections that get in your eyes, if this drug had been tested in a Collie dogs and a certain type of mouse. This drug would never have been invented. It could have killed “Lassie“.

Why is this relevant. There are genetic variants of a protein called P-glycoprotein. This is a drug pump that is very highly expressed in the blood vessels of the brain. It keeps fatty drugs out of the brain.

The MDR-1 mice do not have p-glycoprotein and so they cannot pump ivermectin out of the brain and this means the drugs goes into the brain, it kill nerves. It causes the problem in Collie dogs and this possibly the problem for the Pot worker. Ivermectin has been used safety in many humans , and we all know that asparin is used safely in many humans, but it can have issues.


and ...

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

Pain in your neck and back
Serious eye problems. Symptoms can include:
redness
bleeding
swelling
pain
loss of vision
Shortness of breath
Inability to control urination
Inability to control bowel movements
Trouble standing or walking
Confusion
Extreme tiredness
Extreme drowsiness
Seizures
Coma
Low blood pressure, especially when you get up after sitting or lying down. Symptoms can include:
lightheadedness
dizziness
fainting
Severe skin reactions. Symptoms can include:
severe rash
redness
blistering skin
peeling skin
Liver damage. Symptoms can include:
tiredness
nausea
vomiting
loss of appetite
pain on the right side of your stomach
dark urine
yellowing of your skin or the whites of your eyes


**************

Damn, the level of desperation is not only stupid, it is plain DANGEROUS!



CountAllVotes

(20,874 posts)
12. and you better hope the child does not ingest it!
Tue Apr 14, 2020, 03:24 PM
Apr 2020


When will people wake up to the fact that we are all being poisoned literally to DEATH!



Hortensis

(58,785 posts)
14. :) Well, when my children brought lice home
Tue Apr 14, 2020, 03:30 PM
Apr 2020

from school, I confess I was extremely glad to be able to poison them, and my husband and I. Tying them up in plastic bags with their stuffed toys to get rid of the lice was not an option. And as a working mom, spending a week at home working through their hair with a lice comb for hours each day was also just not an option, though it would, strictly speaking, presumably have been healthier.

CountAllVotes

(20,874 posts)
15. I used the word "ingest"
Tue Apr 14, 2020, 04:08 PM
Apr 2020

as in to swallow.

You really don't care to go there.

That comb does the job and wouldn't you be glad to know that it may have prevented your child from getting sick due to exposure to a poison?

I would NEVER use this crap on any living thing, animal, vegetable or mineral after what I witnessed.



Hortensis

(58,785 posts)
18. No, they were both poisoned too. Poison, then comb to
Tue Apr 14, 2020, 05:24 PM
Apr 2020

get their eggs out. Product recommended and prescribed by the health department.

We didn't have the web back then, and it's such an incredible resource for parents. One night in desperation I called a child psychiatric research institute near my home in West Hollywood when Dr. Spock had failed me and my one-year-old again. I was such a kid. Fortunately a nice psychiatrist was still there and came through with sensible advice any good mom would have if I could have reached one.


CountAllVotes

(20,874 posts)
19. I had them too
Tue Apr 14, 2020, 06:29 PM
Apr 2020

I was a tiny kid at that time and caught them from another girl in the neighborhood.

I can remember little about it except wow was my mother ever pissed!

*whew*

Anyway, she had that comb and was cussing away at me.

If was a different time for sure!

That's I why I so remember the thing with the comb so well -- trauma.

I'm sure she used something like sheep dip on.

Bizarro world back then BUT not as many chemicals yet.

Hortensis

(58,785 posts)
21. :) You got the easy end. Upholstery, carpet, wardrobes,
Tue Apr 14, 2020, 07:09 PM
Apr 2020

as said toys, bedding, everyone, have to be deal with basically at once, not over time. Not surprised your mom's reaction is memorable.

I had to be at a meeting an hour away the next morning and fly out the next afternoon. Got list of requirements and prescription materials down at the health department after our pediatric group wouldn't give an appointment for two days (then I was mad!), called all our friends to warn them, washed everything that could be washed and vacuumed, bag tied off, everyone working, arranged to meet the floating school nurse at a local high school at 6 the next morning to get the kids signed off and in school. On the plus side was, after a pack of running around, the family sitting together on the front steps combing and picking over each other's heads like a pack of baboons.

Memories.

Hopefully there's something to this as a treatment for those symptomatic care may lose.

mn9driver

(4,425 posts)
9. This is the active ingredient in my dog's heart worm pills.
Tue Apr 14, 2020, 02:49 PM
Apr 2020

One dose per month during heart worm season. It doesn’t seem to bother her.

CountAllVotes

(20,874 posts)
13. Very true!
Tue Apr 14, 2020, 03:27 PM
Apr 2020

They do not know WTF they are dealing w/IMO!

So, go ahead and give yourself a few doses of ivermectin and see what happens seems to be the new reality in a desperate move to do anything? This is plain criminal!

How can taking some horse wormer possibly hurt after all?

They are grasping at straws!

dump is desperate to get the DOW going full blast again just before the election comes!


Dem2

(8,168 posts)
16. There is a small amount of clinical information in the article:
Tue Apr 14, 2020, 04:27 PM
Apr 2020
Separately, a small observational registry-based study spearheaded by researchers at the University of Utah found that “critically ill patients with lung injury requiring mechanical ventilation may benefit from administration of Ivermectin.”

“We noted a lower mortality and reduced healthcare resource use in those treated with ivermectin,” wrote Dr. Amit Patel, the lead author of the University of Utah team. Dr. Patel also went onto say that main contraindication is in patients with liver failure and the risk profile may not be as significant as the combination of hydroxychloroquine and azithromycin.

CountAllVotes

(20,874 posts)
17. a small observational registry-based study
Tue Apr 14, 2020, 04:53 PM
Apr 2020

A small study is not good enough.

You need at least 30 subjects for a study.

For it to have any efficacy at all, you need many more studies, not just one small observational one.





Horse with no Name

(33,956 posts)
20. So this stuff works topically as well
Tue Apr 14, 2020, 06:33 PM
Apr 2020

I used it to worm and debug rabbits. .25 ml on the nape of the neck monthly worked like a charm.

LetMyPeopleVote

(145,274 posts)
23. "We won't get vaxed....Now if you'll excuse us, we're off to the farm store for animal medicine."
Wed Aug 11, 2021, 11:01 PM
Aug 2021

I have seen this drug promoted on the RWNJ sites.


LetMyPeopleVote

(145,274 posts)
24. Major study of Ivermectin, the anti-vaccine crowd's latest COVID drug, finds 'no effect whatsoever'
Wed Aug 11, 2021, 11:11 PM
Aug 2021

The RWNJ sites are really pushing this quack cure. This medicine is for horse deworming




Ivermectin, the latest supposed treatment for COVID-19 being touted by anti-vaccination groups, had “no effect whatsoever” on the disease, according to a large patient study.

That’s the conclusion of the Together Trial, which has subjected several purported nonvaccine treatments for COVID-19 to carefully designed clinical testing. The trial is supervised by McMaster University in Hamilton, Canada, and conducted in Brazil.....

Among the 1,500 patients in the study, he said, Ivermectin showed “no effect whatsoever” on the trial’s outcome goals — whether patients required extended observation in the emergency room or hospitalization.

“In our specific trial,” he said, “we do not see the treatment benefit that a lot of the advocates believe should have been” seen.....

The findings on Ivermectin are yet another blow for advocates promoting the drug as a magic bullet against COVID-19. Ivermectin was developed as a treatment for parasitical diseases, mostly for veterinarians, though it’s also used against some human parasites.
Latest Discussions»General Discussion»Head lice drug emerges as...