Autoimmune-disease drugs may reduce vaccine response; antibody treatments ineffective vs Brazil vari
vs Brazil variant
"Autoimmune disease treatments may reduce vaccine responses
Immunosuppressive drugs for inflammatory diseases like rheumatoid arthritis, multiple sclerosis, and ulcerative colitis can impair the body's response to the COVID-19 vaccines from Pfizer/BioNTech and Moderna, according to new data. In 133 fully vaccinated people with such conditions, antibody levels and virus neutralization were about three-fold lower than in a comparison group of vaccinated individuals not taking those medicine, researchers reported on Friday on medRxiv ahead of peer review. Most patients in the study "were able to mount antibody responses in response to SARS-CoV-2 vaccination, which is reassuring," said coauthor Alfred Kim from Washington University School of Medicine in St. Louis. It is not clear yet whether reduced antibody levels will result in decreased protection from infection or hospitalization, Kim said.
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Most antibody drugs ineffective against Brazil variant
The coronavirus variant first identified in Brazil, known as P.1, is resistant to three of the four antibody therapies with emergency use authorization in the United States, according to a laboratory study. In test-tube experiments, researchers exposed the P.1 variant to various monoclonal antibodies, including the four currently being used to treat U.S. COVID-19 patients - imdevimab and casirivimab from Regneron Pharmaceuticals, and bamlanivimab and etesevimab from Eli Lilly and Co. Only imdevimab retained any potency, researchers found."
https://www.reuters.com/article/us-health-coronavirus-science/autoimmune-disease-drugs-may-reduce-vaccine-response-antibody-treatments-ineffective-vs-brazil-variant-idUSKBN2BZ2H1
Bottom line, GET THE VACCINE if you are able. Ideally, the Moderna or Pfizer/BionTech, until they fully understand the mechanism for the AstraZeneca and JNJ rare clotting issues, and a viable antidote should such an issue arise, or a way to prescreen someone for vulnerability
The reason this information is important is because even after getting the vaccine, it is still prudent when out in public situations to mask up, and take certain precautions