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Celerity

(45,393 posts)
Sat Sep 25, 2021, 07:38 PM Sep 2021

Moderna booster (given at 5 months post 2nd jab) report. We finally had a reaction after no effects

from either asymptomatic origin-strain Covid back in late April early May 2020, and then 2 South African (Beta) variant-tweaked mRNA-1273.351 Moderna initial jabs (the 2nd one around 5 months back) as part of a trial here in Stockholm.

Thursday we got (as part of an additional, very small experimental trial) jabbed for the 3rd time and this was with the new Moderna mRNA-1273.617 Delta variant tweaked vax (100 µg dosage).

We had almost no reactions to the Beta variant jabs other than sore arms for like 12 hours or so.

Not this time, lolol.

By around 20 00 to 2200 (we got them at 14 00) we were both asking what type of lorry had run us over. Fever (over 100F) chills, headache from hell, and night sweats all night long, plus sore arms (the same intensity as the first two). Friday we were still not 100% recovered but had far less symptoms and no fever. Sore arms were gone by nightfall Friday. By this morning (Saturday) most all symptoms have disappeared for both me and wifey.

That first night was rough, sickest either of us had been in years tbh, but it came and went fairly quickly. I had the added 'pleasure' of some serious PMS as well (non vax related of course).

The doctors warned us to expect a heavy duty reaction based off a similar trial already running in the US.

I will post again when we get the results of a blood draw on October 7th. Moderna is no longer going to run with the beta variant specific only trials, at least not here in Sweden.

They also are testing a new multivalent vax, mRNA-1273.213, a candidate combining the Beta-specific and Delta-specific candidates. Our results (because we got both as single variant vaxes, so a similar profile) will be compared to that one.



That mRNA-1273.213 vax is one of the most likely variant-tweaked vaccines that could be made available to the general public (or so our doctors say, and of course they are speaking about Sweden, they would not make statements about the US). They also said that Pfizer (actually it is their partner, in Germany, BioNTech, that is running point on this) is already in trials with Delta variant (and all other variants as well, the same as Moderna os doing) tweaked vaccines too. Both Moderna and BioNTech can switch variant types on vaccines in less than 4 weeks. It is amazing technology.

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Celerity

(45,393 posts)
3. They all exist now, they are in trials. I am not privy to what routes to market will be taken. We
Sat Sep 25, 2021, 07:56 PM
Sep 2021

are just the guinea pigs/lab rats who want to help out as best we can. Every visit we make we stress as best we can that we hope Moderna makes these variant tweaked boosters available ASAP (of course after due diligence with prelim studies for safety purposes). That said, we have basically zero actual input power, other than our blood.

Pfizer did a major backtracking in July and August. Publicly up until then they had said they saw no need for variant specific tweaked vaccines atm. Apparently Delta's continuing rampage has changed their mind. I think it is being driven more by the German end (BioNTech) than the US end (Pfizer) of the partnership. Moderna was more open to it (as evidenced by our trial study that started over 6 months ago now, and also comments from our trial doctors, who are NOT Moderna nor BioNtech employees, and thus are neutrals) from the beginning (from all that I can gather).

Rhiannon12866

(212,467 posts)
5. Thanks for all the information and for putting yourselves out there to help
Sat Sep 25, 2021, 10:05 PM
Sep 2021

I got the Moderna vaccine, second shot March 28th, and though I just had the sore arm after shot #1, I had real side effects after shot #2, very bad chills, nausea and I was afraid to get up because I felt so woozy. Looks like I may have more of that to look forward to when I finally get a booster.

Celerity

(45,393 posts)
6. The doctors said that one of the reasons that the Delta tweaked vax elicits such a strong reaction
Sat Sep 25, 2021, 10:11 PM
Sep 2021

could be due to the fact that Delta itself is so much more virulent than other variants of the COVID virus itself, and the bio-processes by which the mRNA vaccines work trigger off a tonne of disease-fighting components that increase the side effects. Obviously that is not a definitive answer, but they seemed to be pretty sure it was one of the underlying causes.

Rhiannon12866

(212,467 posts)
8. Thanks for the information and it does make sense
Sat Sep 25, 2021, 10:33 PM
Sep 2021

When I felt so awful after shot #2 I just figured that this meant it was working and the symptoms weren't going to last, which they didn't. It wasn't pleasant to go through, but avoiding Covid is definitely worth it. Thanks for letting us know what's going on - and for all you've done to make it possible for the rest of us to be protected.

ananda

(29,313 posts)
9. Thank you for participating.
Sun Sep 26, 2021, 03:59 PM
Sep 2021

I got Moderna, so I have a special interest in its boosters.

I think you are wonderful for doing this.

ret5hd

(20,855 posts)
2. Do you receive 5G and/or WiFi directly...
Sat Sep 25, 2021, 07:55 PM
Sep 2021

in your brain now? Do you need to hold your dinnerware with a firmer grasp?

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