Several FDA-Approved Anti-Cancer Drugs Induce Stem Cell Tumors, Perhaps Thwarting Therapy
UMassAmherst
March 10, 2014
Contact: Janet Lathrop 413/545-0444
AMHERST, Mass. – Using a new approach to systematically test chemotherapy drugs in an unusual animal model, a research team led by University of Massachusetts Amherst molecular biologist Michele Markstein, with Norbert Perrimon at Harvard Medical School, report that several have a serious side effect: Inducing hyper proliferation in stem cells that could lead to tumor recurrence.
Markstein says, “We discovered that several chemotherapeutics that stop fast growing tumors have the opposite effect on stem cells in the same animal, causing them to divide too rapidly. This was a surprise, because it showed that the same drug could have opposite actions on cells in the same animal: Suppressing tumor growth on one cell population while initiating growth in another. Not only is the finding of clinical interest, but with this study we used an emerging new non-traditional tool for assessing drugs using stem cells in the fruit fly gut.”
She adds, “We did these experiments in the fly because Drosophila stem cells, in the intestine, are very much like the stem cells in our intestine, and it’s a lot easier to do experiments in flies than humans or even mice.” Their paper appears in the current issue of Proceedings of the National Academy of Sciences.
Further, Markstein explains, “When it comes to stem cells, it is important to conduct studies in living animals because stem cells are acutely attuned to the other cells in their microenvironment. Indeed the side effect that we observed is caused by damage that the chemotherapy drugs cause to cells in the stem cell microenvironment. The stem cells respond to this damage by hyper proliferating.”
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- How many more people will the FDA kill before they're stopped? 
= new reply since forum marked as read
...because I think anything we do at this point to try and repair the damage that has been rendered against us and this society, is merely cosmetic at-best. Fixing the problems at the FDA is like trying to fix one the nodules of mold on the below rotten apple and expecting for that to do the trick. The corruption is complete.
- As Terence McKenna suggested: ''The data stream has been corrupted, return to first principles.''
When those impacts are from a natural source (lead, mercury, natural radioactive substances), our bodies tend to be able to handle them better because the exposures are usually low and limited. There are also those who possess a genetic predisposition for cancers (as well as to fight it), as Nature believes in diversity in all directions.
However, with the dawn of the modern era, we've allowed ourselves to be inundated with chemicals and poisonous substances without parallel. There are few people who have not been exposed to these chemicals today, as they have become ubiquitous. And unless those chemical impacts are mitigated in some way through diet, genetic robustness, etc., then the cancers will continue to proliferate.
Cancers are created when our own cell's DNA programming has been damaged (usually via chemicals we consume like GMO foods and petro-chemicals and plastics made from it, to name just a few) and which then fail to complete their life-cycles ending in apoptosis (cell death).
Apoptosis can be achieved through the application of cannabinoids: Endo-cannabinoids are those that our own bodies produce and are responsible for those cases of spontaneous cancer healing that people sometimes exhibit. Phyto-cannabinoids are those found in plants, cannabis having the highest concentrations. And Artificial-cannabinoids which the feds are now issuing patents for to privately owned pharmaceutical companies so that they can charge us for the cures Mother Nature has already provided to us.
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Typical of the alt-med, cannibis cures cancer, woo crowd to extrapolate a preliminary study done on fruit flies to "How many more people will the FDA kill before they're stopped?"
Sid
