Possible Alzheimer's Prevention Breakthrough Reported

[appalachiablue]

Source: CBS News

Albuquerque, N.M. -- Researchers at University of New Mexico believe they may have found a way to prevent Alzheimer's disease, reports CBS Albuquerque affiliate KRQE-TV.

UNM's Health and Sciences Department Associate Professor Kiran Bhaskar, who's been passionate about studying the disease for the last decade, says the search for a cure started with an idea in 2013.

"I would say it took about five years or so to get from where the idea generated and get the fully functioning working vaccine," he says.

Bhaskar and his team started to test the vaccine on mice. "We used a group of mice that have Alzheimer's Disease, and we injected them over a series of injections," says PhD student Nicole Maphis. Maphis says the vaccine targets a specific protein known as tau that's commonly found in the brains of Alzheimer's patients. - MORE...


Read more: https://www.msn.com/en-us/health/medical/possible-alzheimers-prevention-breakthrough-reported/ar-AACI2FX?ocid=HPCOMMDHP15

---

Mice were given a series of maze-like tests; mice that received the vaccine performed a lot better than those that hadn't.
> This isn't a complete success just yet, being able to get the vaccine to people will not only take a few more years, but could cost up to $1 billion.
> Once they develop a vaccine that's safe for humans, ii must be submitted for FDA for approval that might take another five years.

Almost 1/3rd of seniors are affected by Alzheimer's and it's "on the rise, currently affecting 43 million people worldwide," UNM notes.

[MontanaMama]

1. Wouldn't this be something?

my Dad and grandfather both succumbed to early onset Alzheimer’s. I welcome any progress in treatment.

[Brainfodder]

11. Sure would and hopefully leads to advancement on many others!

My parents are at that age of concern, and both grandparents on one side had at least dementia for a while at the end.

Important:
Fixes need to be affordable!

[appalachiablue]

13. The vaccine must be affordable, absolutely.

[olegramps]

26. I would hope that this could be fast tracked due to the massive necessity.

[demosincebirth]

75. I hope so.

[pandr32]

2. Really hopeful about this

My Grandmother, Mother, and two aunts (one paternal, one maternal) suffered dementia and died after a horrible period of slow decline and incidents that could have been right out of a horror movie.

It is so hard for those who suffer and those of us who love them.

[trev]

61. My mother did, too.

I've lived my life in fear that I will contract it.

[Cal Carpenter]

73. Ditto n/t

[50 Shades Of Blue]

3. K & R

Fingers crossed!

[lark]

4. Of course it's not a natural cure.

I hope it works and also hope it won't cost and arm and a leg, but that's probably going to happen. I've seen reading a book that says that fasting for 12 hours/day is also a great dementia preventer and even helps slow the deciine. I had 2 head traumas in 6 weeks, so am trying this to help reduce inflammation on my brain. Hope it works.

[Laura PourMeADrink]

9. Really? Fasting how often? A relative passed on info

From her BIL who is researcher in Chicago. He said they only knew two things for certain. People who don't get dementia read novels and drink 2+cups of coffee a day. Said reading a story submerges your brain completely into another life and place...which is good for it.

[lark]

12. Calls for permanent fasting, not eating from 8pm to 8am.

I actually used to eat like that as a young adult and was thin and "with it". I've just recently started trying to do this again, still not great at denying myself the late night snacks I got used to, but looking at this as transitioning to that.

Wow, thank you for the 2+ cups of coffee and a story. I drink 3 cups a day and read at least an hour a day and usually it's several and mostly novels. So that makes me feel good about the long term results of completely recovering from my 2 concussions and all the damage that did plus not getting dementia.

[Doitnow]

21. What do CBD and BIL stand for? Pretty soon whole sentences will be acronyms!

[lunatica]

23. CBD is hemp oil which you can take for pain

It’s perfectly safe and you don’t get high. You take it with a dropper under your tongue. It has a lot of other benefits. Well worth doing some research on. I think BIL is short for brother in law.

[lark]

31. I didn't use those, but I know what they are.

CDB, not sure the exact name but it's cannabis oil without the thc - the component that gets you high.
Bil - brother in law

[Bernardo de La Paz]

37. CBD, not CDB. . . . nt

[klook]

76. Yes:

[Bernardo de La Paz]

36. CannaBiDiol and Brother-In-Law. Cannabidiol is not psychoactive. . . . nt

[Beartracks]

62. ... but a brother-in-law COULD be.

===========

[Bernardo de La Paz]

39. "Fasting" 8pm to 8am? That's NORMAL! Why do you think it is called BREAKfast?

That's NOT fasting. That's normal.

Late-night snacks are NOT NORMAL.

[lark]

46. I haven't eaten like that since I was in my 40's.

I started working long hours and rarely got home before 8pm so generally ate around 9 or would just have an immediate snack then eat something small before I went to bed. I ate breakfast around 7, so my non-eating was only from 9:30 - 7, not 12 hours so I gaind weight. I did that for 20 years and now have the habit of eating later and it's hard to break.

BTW - the snark was unnecessary and not nice.

[Bernardo de La Paz]

47. Ah, that makes sense. Sorry, it was snark against the promoters labeling it fasting, not you.

Good wishes finding the right food regimen for yourself. Nutrition and gut health are foundational to all health, so it is the right kind of quest.

For you:

https://www.health.harvard.edu/blog/intermittent-fasting-surprising-update-2018062914156

A study in Alabama with obese pre-diabetic men found that fasting 16 hours daily worked better than the more normal 12 hours: eating 7am to 3pm vs eating 7am to 7pm.

I'd say that by extension this supports the concept that 12 hours daily with no food might be better than 8 hours with no food.

[Laura PourMeADrink]

56. I was thinking the same thing. :). But maybe it

Relates to how important good sleep is and perhaps that food digestion can affect sleep? I don't know. But did have a 1980s flashback...a diet that was the fad at the time. You couldn't eat within 8 hrs of going to sleep. Remember a guy at work who ate supper at 3pm. He lost tons of weight.

[Bernardo de La Paz]

40. It's NOT reading. That's association, not causation. There are other REAL activities to stave off A

There are several real things that hold it off (as much as it can be held off). People who do these things are likely to read, so the reading is merely associative. I'm sure it helps a bit in itself, but studies have found the following things help:

* Crossword puzzles (new words and new ways of thinking of words)

* Playing a musical instrument (engages memory and coordination with complex patterns)

* Playing mental games of skill like Chess and Go (igo, baduk, weiqui) where opponents are always creating new patterns

* Gardening (exercise, meditation, planning, working with patterns)

* Dancing (aerobic exercise, coordination with complex patterns)

I'm doing three of those and trying to get myself to regularly spend a little time learning a musical instrument.

[Laura PourMeADrink]

42. I am not a doctor or scientist...just passing on what

An Alzheimer's researcher passed on to us. Operative word - novel reading. Coffee. And actually, he said they had proven that crosswords do nothing to help. So there you have it.

[Bernardo de La Paz]

49. I vaguely remember crosswords being "disproven" so I searched and found the opposite

I think it is a lifetime of intellectual and physical activity that has the biggest effects. Never too late too start, but best to start in youth.

* 40 year study with reference to crossword puzzles and reading as example activities. From 2012, article from 2019.
http://sciencenordic.com/crosswords-knitting-and-gardening-lower-risk-alzheimers

* Long term Finnish study w 1000 people, from 2015. Reported in Lancet.
https://www.theguardian.com/society/2015/mar/12/dancing-sudoku-fish-and-fruit-the-keys-to-a-mentally-alert-old-age

I think there is confusion between evidence for reduction in amyloid plaque versus evidence for the reduction of mental deterioration.

I seems that studies show no reduction of plaque but reduction of mental deterioration. Mechanism versus outcomes.

And coffee is good for several reasons including anti-oxidants and stimulation. In moderate doses (2-4 cups daily depending on weight and other factors).

[Laura PourMeADrink]

52. Yes...my thought is that the research he is doing

Is more related to commonalities and figuring out what the magic mix is of do's and don't's. The analytical side vs. the medical side.

I should have explained that better. And that the novel reading and immersion into another world and the coffee drinking were pretty much portrayed as a "they were light years away" from figuring it out with data and analytics.

If you think about it, it's an astounding task. With infinite factors and combinations and who knows if they have all the factors even needed about people's lives.

My dad began to notice memory loss about 30-35 years ago when he and my mom had ordered dinner and he then began to look around for a waiter to take their order. Been extremely slow decline since then. But this past Christmas went up there and we all bowled like they did every week and went to the casino. Since then, it has been rapid. He's 97 and my mom who is in perfect health, takes care of him. She is 94.

Sorry to go on so much. It is just such an incredibly horrible disease. For my mom and for him. To know is horrifically sad. And trust me, there is no good financial way either. Thankfully he signed the house over to my mom in 2014.

[Cetacea]

77. "confusion between evidence"

Non alzheimer's dementia versus dementia from other causes perhaps?

[srobertss]

24. Maybe novels helped my mother

but in her case, they didn’t ultimately prevent Alzheimer’s. She was reading clear up to the end, although I had two sets of three books I gave her in rotation, because she didn’t realize she’d already read them. She was also able to play bridge clear up to the end, though she was continually reintroducing herself to her fellow players every week. She pretty much knew me as well, but the repetition of questions was non stop. It’s amazing how differently the disease plays out among people.

I’ve had nightmares about having memory loss and waking up is such a relief.

[Stonepounder]

30. Didn't work with my mom.

She was a voracious reader and passed her love of books down to me. She was only in her 50's when she was hit with early-onset Alzheimer's. My dad cared for her at home as long as he could, but finally had to institutionalize her. Shortly thereafter he was asked not to visit any longer, since she had no idea who he was and it upset her 'routine'. She died in her late 60's with no real conscious mind left. She had to be fed because she had forgotten how to eat.

[MontanaMama]

33. Didn't work for my dad wither.

Like you describe, he was a voracious reader and read anything and everything he could get his hands on. Dad built computers for fun! He died at 69 years old...he wasn't eating on his own or speaking. Although, the week before he died, he held my hand and said "Honey, I'm going to go." It was the first time he'd spoken in months and they were his last words and they are so precious to me.

[Laura PourMeADrink]

43. Yes the way I took it was that those are the only two things, reading

novels and drinking coffee that they have figured out could be many many more. And many many more that people don't do. Like a giant puzzle. Probably gonna need lots and lots of data, plus analytics to figure it out.

[mahina]

64. Here's something. I'm going to go mind my own business now.

194 citations
https://www.ncbi.nlm.nih.gov/m/pubmed/19864195/


Risk factors for dementia.
Review article
Chen JH, et al. J Formos Med Assoc. 2009.
Show full citation
Abstract
Dementia is a complex human disease. The incidence of dementia among the elderly population is rising rapidly worldwide. In the United States, Alzheimer's disease (AD) is the leading type of dementia and was the fifth and eighth leading cause of death in women and men aged > or = 65 years, respectively, in 2003. In Taiwan and many other counties, dementia is a hidden health issue because of its underestimation in the elderly population. In Western countries, the prevalence of AD increases from 1-3% among people aged 60-64 years to 35% among those aged > 85 years. In Taiwan, the prevalence of dementia for people aged > or = 65 years was 2-4% by 2000. Therefore, it is important to identify protective and risk factors for dementia to prevent this disease at an early stage. Several factors are related to dementia, e.g. age, ethnicity, sex, genetic factors, physical activity, smoking, drug use, education level, alcohol consumption, body mass index, comorbidity, and environmental factors. In this review, we focus on studies that have evaluated the association between these factors and the risk of dementia, especially AD and vascular dementia. We also suggest future research directions for researchers in dementia-related fields.

PMID 19864195 [Indexed for MEDLINE]
Full text
Full text at journal site
Similar articles

Prevalence and subtypes of dementia in southern Taiwan: impact of age, sex, education, and urbanization.
Lin RT, et al. J Neurol Sci. 1998.
Can dementia be prevented? Brain aging in a population-based context.
Review article
Haan MN, et al. Annu Rev Public Health. 2004.
[Vascular risk factors in demented elderly: analysis of Alzheimer Clinic materials].
Czyzewski K, et al. Neurol Neurochir Pol. 2001.
Midlife risk factors for subtypes of dementia: a nested case-control study in Taiwan.
Chiang CJ, et al. Am J Geriatr Psychiatry. 2007.
Smoking is associated with an increased risk of dementia: a meta-analysis of prospective cohort studies with investigation of potential effect modifiers.
Review article
Zhong G, et al. PLoS One. 2015.
See all

[appalachiablue]

70. 'Several'? everything but the kitchen sink. Come on NIH, this broad..

>"Several factors are related to dementia, e.g. age, ethnicity, sex, genetic factors, physical activity, smoking, drug use, education level, alcohol consumption, body mass index, comorbidity, and environmental factors.

In this review, we focus on studies that have evaluated the association between these factors and the risk of dementia, especially AD and vascular dementia. We also suggest future research directions for researchers in dementia-related fields."

[mahina]

71. There are lots of studies. You can search the published journal articles on pubmed directly.

I just picked one with tons of citations. Find all here: https://www.ncbi.nlm.nih.gov/pubmed/

From the quick start guide:

Clinical study category

The clinical study categories use built-in search filters that will limit retrieval to citations to articles reporting research conducted with specific methodologies, including those that report applied clinical research. To find citations for a specific clinical study category:

1.
Click Clinical Queries from the PubMed homepage or from the advanced search more resources menu.

2.
Enter your search terms in the search box, and then click search.



It’s our research and it’s available for all of us to read, at least the abstracts.

[Laura PourMeADrink]

72. Thanks Mahina! You rock

[mahina]

74. Na Laura it's not mine.

Glad if it’s helpful! It was a big help for me too, not to just wait to randomly hear about a relevant study or just google. This provides actual data.

Of course we still have to notice who finds the studies

[appalachiablue]

82. NIH and PubMed are valuable for sure, thanks for posting.

[Laura PourMeADrink]

53. That is interesting. I have often thought...you might be

doing the right things all your life and you benefit by not getting it sooner rather than later. Did she know? My Dad's doctor always believed in not using the dementia or Alzheimer's word ever. In my mind, the best transition would be from knowing you are losing your memory to not remembering that.

[srobertss]

65. My mother knew

She was always saying, “I can’t believe what an idiot I’ve become.” And when my older brother died she couldn’t understand why she couldn’t feel the grief properly. She kept saying, “What have I become?” In my nightmares I know I’ve lost my memory and it’s like I’ve lost a mental anchor. I keep fishing around for something to latch on to to bring back my focus. I have no idea if that’s what it’s really like, but it isn’t fun.

[mahina]

45. I searched "pubmed, dementia, coffee,novels"

https://www.ncbi.nlm.nih.gov/pubmed/20182054


J Alzheimers Dis. 2010;20 Suppl 1:S167-74. doi: 10.3233/JAD-2010-1404.
Caffeine as a protective factor in dementia and Alzheimer's disease.

Eskelinen MH1, Kivipelto M.
Author information
Abstract
Caffeine has well-known short-term stimulating effects on central nervous system, but the long-term impacts on cognition have been less clear. Dementia and Alzheimer's disease (AD) are rapidly increasing public health problems in ageing populations and at the moment curative treatment is lacking. Thus, the putative protective effects of caffeine against dementia/AD are of great interest. Here, we discuss findings from the longitudinal epidemiological studies about caffeine/coffee/tea and dementia/AD/cognitive functioning with a special emphasis on our recent results from the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study. The findings of the previous studies are somewhat inconsistent, but most studies (3 out of 5) support coffee's favorable effects against cognitive decline, dementia or AD. In addition, two studies had combined coffee and tea drinking and indicated some positive effects on cognitive functioning. For tea drinking, protective effects against cognitive decline/dementia are still less evident. In the CAIDE study, coffee drinking of 3-5 cups per day at midlife was associated with a decreased risk of dementia/AD by about 65% at late-life. In conclusion, coffee drinking may be associated with a decreased risk of dementia/AD. This may be mediated by caffeine and/or other mechanisms like antioxidant capacity and increased insulin sensitivity. This finding might open possibilities for prevention or postponing the onset of dementia/AD.
PMID: 20182054 DOI: 10.3233/JAD-2010-1404
[Indexed for MEDLINE]
Share on FacebookShare on TwitterShare on Google+
Publication type, MeSH terms, Substances

https://www.ncbi.nlm.nih.gov/pubmed/29807456
Send to
Dementia (London). 2018 Jan 1:1471301218778398. doi: 10.1177/1471301218778398. [Epub ahead of print]
Dementia and detectives: Alzheimer's disease in crime fiction.

Orr DM1.
Author information
Abstract
Fictional representations of dementia have burgeoned in recent years, and scholars have amply explored their double-edged capacity to promote tragic perspectives or normalising images of 'living well' with the condition. Yet to date, there has been only sparse consideration of the treatment afforded dementia within the genre of crime fiction. Focusing on two novels, Emma Healey's Elizabeth is Missing and Alice LaPlante's Turn of Mind, this article considers what it means in relation to the ethics of representation that these authors choose to cast as their amateur detective narrators women who have dementia. Analysing how their narrative portrayals frame the experience of living with dementia, it becomes apparent that features of the crime genre inflect the meanings conveyed. While aspects of the novels may reinforce problem-based discourses around dementia, in other respects they may spur meaningful reflection about it among the large readership of this genre.
KEYWORDS:
Alzheimer’s disease; crime fiction; dementia; detective fiction; genre; literary gerontology; representation

[Laura PourMeADrink]

54. Interesting. So reading and dementia didn't pop up

huh.

[mahina]

57. I just didn't search that term.

So just now I searched:
Pubmed dementia reading

You should probably take a look yourself. There are heaps of peer reviewed journL articles.

Here’s one:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1151037/

Mental activity may help prevent dementia

Scott Gottlieb

Additional article information

Participating in mentally challenging leisure activities such as reading and playing board games may help elderly people stay mentally sharp. Researchers found that people aged 75 years or more who engaged in leisure activities had a lower risk of dementia than other elderly people. It is unclear whether increased participation in leisure activities lowers the risk of dementia or whether participation in such activities declines during the preclinical phase of dementia (New England Journal of Medicine 2003;348:2508-16). But not all activities seem to be equally effective in reducing the risk of dementia. People who reported often playing board games, reading, playing a musical instrument or doing crossword puzzles were less likely to develop dementia than people who said they engaged in those activities only rarely. However, writing and taking part in group discussions seemed to offer no protection against memory-robbing conditions such as Alzheimer's disease. The researchers followed a cohort of 469 people aged over 75 who lived in the community and did not have dementia at the start of the study. They measured how often the people took part in leisure activities, deriving a cognitive activity score and a physical activity score for each person. These were composite measures that took account of all of the cognitive or physical activity of each person. Researchers adjusted the scores for age, sex, level of education, presence or absence of chronic medical illnesses, and baseline cognitive status. The participants were followed for up to 21 years. More than half the participants were followed for at least five years. Over a median follow up period of 5.1 years dementia developed in 124 people (Alzheimer's disease in 61 people, vascular dementia in 30, mixed dementia in 25, and other types of dementia in eight). Among the leisure activities reading, playing board games, playing musical instruments, and dancing were associated with a lower risk of dementia. An increase of one point in the cognitive activity score was significantly associated with a lower risk of dementia (hazard ratio 0.93 (95% confidence interval 0.90 to 0.97), but there was no association between a one point increase in the physical activity score and risk of dementia. The study's lead author, Dr Joe Verghese, of the Albert Einstein College of Medicine in New York, said that cognitive activity may stave off dementia by increasing a person's "cognitive reserve." For instance, mental exercise may increase the connections between brain cells or promote new networks between cells, he said. So, while people who engage in these activities may get dementia as often as other people, mentally active people can perhaps afford to lose more brain cells before the symptoms appear. Researchers have shown that people who develop dementia tend to halt their activities as a result. Consequently experts have debated whether people who do less mental exercise and later develop dementia are inclined to abandon their activities because they had an early, undetected form of the disease. To address this concern the researchers excluded people who developed dementia in the first seven years of the study, as they might have had an early form of the disease when the study began. In an accompanying editorial Dr Joseph Coyle, of Harvard Medical School in Boston, agreed that promoting leisure activities among elderly people couldn't do any harm and might help. While researchers continue to investigate the relative contributions of genes and the environment to dementia, "seniors should be encouraged to read, play board games, and go ballroom dancing, because these activities, at the very least, enhance their quality of life, and they just might do more than that," he writes.

Article information

BMJ. 2003 Jun 28; 326(7404): 1418.
PMCID: PMC1151037
Scott Gottlieb

[Laura PourMeADrink]

60. thanks SO much for finding this. Extremely interesting Mahina !

[mahina]

63. Easy as pie. Just search with the term 'pubmed' for peer reviewed journal articl s

Or at least the abstracts. The more the article was cited. The more
Important people think it is.

It’s our research. Dipshit hasn’t taken that away

[zipplewrath]

10. Define "natural"?

Especially with CBD oil becoming so popular, I'm not sure where the distinction starts.

[lark]

14. I'd include CBD in natural, but I don't know a lot bout that..

It's just become leal here (medical only) and I hadn't heard anything about it helping brains Are there versions that do this effectively?

[zipplewrath]

17. anxiety

Most of the success I've heard with the CBD oil has been as an anti-anxiety. I've heard of folks using it for a Zanax replacement.

[BigmanPigman]

29. It works on dogs.

My neighbor's dog had nighttime dementia and she gave it Xanax than she tried CBD oil and it worked just as well.

[Laura PourMeADrink]

44. Never heard of nightime dementia. We lost our dog

Last September, but he developed anxiety at night...and with thunder... neither had he had before. Wonder if that is the same ? Although could have been the bone cancer.

[BigmanPigman]

48. I never heard of it either but after I did

I discovered it is fairly common. None of the dogs I have had during my life ever had it but my dog who is 16 started to get up and roam around at night recently and I gave her some of the oil and it made her settle down. I never tried my Xanax on her though. I need it more than she does....especially now with the fucking moron in the W House!

[Laura PourMeADrink]

55. You are funny BG !!!!! Does the dog drink it? Duh

Or you rub on coat???

[BigmanPigman]

59. It tastes gross!

I am glad I don't have to taste it! It is liquid and comes with a plunger/syringe without the needle part. How much depends on the size of your dog. Also, after 1-2 weeks you have to increase the amount to get the desired effect then you stay at that amount. Mine only needs it occasionally. Since she is small it isn't too costly (7 pounds).

[Auggie]

16. A doctor I know says physical exercise is a preventative measure

[Honeycombe8]

19. That's good to know. I'm reading up on prevention right now.

So far, I've read that anything that helps prevent vascular disease and cardiovascular disease, helps prevent Alzheimer's. Physical exericse, a heart-healthy diet (they've studied two diets so far that seem to help: DASH, and a Mediterranean diet).

What also MIGHT be helpful:
Intellectual activity
Strong social connections

There's a strong link between head trauma and getting Alzheimer's.

It's good to know that we can do SOMETHING now to help prevent it.

[Bernardo de La Paz]

35. Alzheimers is not due to inflammation on the brain. Completely different mechanism. . . . nt

[Politicub]

58. Fasting for 12 hours is basically skipping breakfast

If you count sleeping time.

I don’t believe this approach works.

[Cetacea]

78. Keto diet as well

I've tried it and it seemed to help with cognition. Difficult to maintain though.

[lark]

85. I like Keto but my husband hates it and he's the cook.

I'm not at my best right now, awaiting surgery, so not doing much cooking. Once I recover from surgery, and start cooking more again, I will probably go back to this.

[Cetacea]

86. Good. And good luck with everything

Feel free to PM me if you need any info I've compiled over the years.

[mopinko]

5. hope this and other promising threads are covered under right to try.

there was another recent story that humira, i think it was, was showing affect on alzheimers in patients taking it.

i have really been dying of curiosity about the side effects of the humabs. i think there might be some interesting surprises in there.

but if i were the patient, i would be grasping at straws, for sure.

[denbot]

6. A kick for my late mother, Angie.

[AllyCat]

7. Watching a family member go through this and helping arrange care

Is horrible, stressful, and sad. I hope this works!

[rurallib]

8. Wow - talk about a big find

This could be some truly great news.

This will give a lot of people a lot of hope.

[PoindexterOglethorpe]

15. Keep in mind this is incredibly preliminary results.

To move from the mouse model to humans is an enormous leap.

[Honeycombe8]

18. That's amazing! That co. is also working on Parkinson's. Imagine if those 2 things...

were able to be eradicated. Amazing.

[lunatica]

25. It's not a company. It's

It’s research done in a university. Companies sometimes will donate funds for the research but so does the NSF - National Science foundation gives grants for all kinds of research. So it’s basically pure science and not for profit.

Usually any patents belong to the University.

http://www.unm.edu/research/index.html

[Honeycombe8]

32. Looks like there are multiple universities and companies working on that.

I thought that United Neursocience was the manufacturer for all of them, but in review, I think that it is also doing the research and testing, in addn to manufacturing and selling of vaccines.

https://www.unitedneuroscience.com/pipeline/

There may be more than one vaccine being developed, with trials going on. And some have been developed with trials already unsuccessfuly concluded.

United Neuroscience (UB 311)
Univers of New Mexico
UT Southwestern (dallas)
Novartis
Araclon Biotech
Lundbeck/Otsuka
Axon Neuroscience
J&J

[lunatica]

34. I'm glad so much research is being done on this horrible disease

It affects every spectrum of humanity so it behooves researchers to come up with a cure. I think it will happen very soon. My mother had Dementia. It’s devastating.

[SleeplessinSoCal]

20. I hope this works. Probably not helpful to those with the disease.

My hubby has been on the spectrum for 4 years. Progressing slowly, but surely. Before then it was MCI for about 5 years.

When is it too late to be effective, I wonder...

[lunatica]

27. The research shows improvement in mice with Alzheimers

Because whatever they’re using attacks the protein plaque that sticks to brain cells which is the cause of Alzheimer’s.

[SleeplessinSoCal]

67. thank you so much for the hopeful news.

We were in a clinical trial for 2 years for a drug that was abandoned a year ago. This would be a Godsend to so many.

[lunatica]

69. There is always hope

My mother had Dementia. When the doctor prescribed Aricept it slowed down the progress of the disease immensely. To me it seemed she was cognitively doing about the same for the last three years of her life. She always knew who I was and she understood us and responded. In the end it was pancreatic cancer that ended her life. She peacefully died at home under Home Hospice care.

I really believe there will be a cure and preventive medicine in the not too far future.

[Doitnow]

22. Pretty soon there will be a vaccine for getting up in the morning!

[wryter2000]

28. A billion would be a bargain

To get rid of this scourge.

[Stuart G]

38. K and R

[Bayard]

41. Make it so

My mom had it for several years before she passed away. Its a horrible thing to watch a loved one decline like that.

Only a prevention though, not a cure. Hopefully they'll come up with that too. Every time I forget something, I start worrying.....

[pat_k]

50. I wonder how what they are testing relates to AADvac1 vaccine trials?

There are human trials already being done on AADvac1:

Upon administration, AADvac1 vaccine induces a patient’s immune system to produce specific antibodies that target abnormal forms of the tau protein. The aim is to protect the neurons from dying.

Early trials were promising and a 24-month randomized, placebo-controlled Phase 2 trial (NCT02579252) involving patients with mild Alzheimer’s disease is currently ongoing. The study, known as ADAMANT, is investigating the safety and tolerability of AADvac1.

https://alzheimersnewstoday.com/aadvac1/

[CentralMass]

51. They will undoubtedly charge an astronomical fee for it.

[Raine]

66. I'll believe it when I see it

I heard this kind of thing time and time again and I'm not holding my breath.

[appalachiablue]

68. Nada about toxins in food and household products which are

loaded with junk, unless organic. And tobacco use has declined significantly, so how much is smoking a causal factor anymore.

[Cetacea]

79. Common anticholinergic drugs like Benadryl linked to increased dementia risk

Many popular OTC drugs are in this category...





https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-201501287667

[appalachiablue]

81. I'd read this too, and also wonder about prescription drug

use in older people - 'polypharmacy.' When several meds are prescribed it's sometimes difficult to determine which one could be causing issues. The case with Mil taking arthritis, BP meds and experiencing cognitive changes, we never knew.

"Anticholinergic drugs include some antihistamines, tricyclic antidepressants, medications to control overactive bladder, and drugs to relieve the symptoms of Parkinson’s disease."

[EarthFirst]

80. Somewhere someone is salivating over the potential profit... nt

[marybourg]

83. I'm happy for them to make a*reasonable* profit,

if they could just help people with Alzheimer’s. This is still a capitalist society.

[yonder]

84. Four comments:

1) If this is developed and it works it would be wonderful for many millions of people and their families.

2) How do we keep corporate pharmaceutical in industry from making obscene profits.

3) "Almost 1/3rd of seniors are affected by Alzheimer's and it's "on the rise, currently affecting 43 million people worldwide," UNM notes." With a world population of some 7.8 billion people, 43 million representing 1/3 of seniors seems small. I think they dropped a zero - 430 million makes more sense.

4) If this is developed and it works it would be wonderful for many millions of people and their families.