The Nobel Prize in medicine goes to 3 scientists for work on peripheral immune tolerance

[BumRushDaShow]

Source: AP

Updated 5:55 AM EDT, October 6, 2025


STOCKHOLM (AP) — Mary E. Brunkow, Fred Ramsdell and Dr. Shimon Sakaguchi won the Nobel Prize in medicine on Monday for their discoveries concerning peripheral immune tolerance.

Brunkow is a senior program manager at the Institute for Systems Biology in Seattle. Ramsdell is a scientific adviser for Sonoma Biotherapeutics in San Francisco. Sakaguchi is a distinguished professor at the Immunology Frontier Research Center at Osaka University in Japan.

Peripheral immune tolerance is one way the body helps keep the immune system from getting out of whack and attacking its own tissues instead of foreign invaders. Their work dates back to 1995, when Sakaguchi made the first key discovery. Brunkow and Ramsdell made another breakthrough in 2001 and Sakaguchi linked all of their work two years later.

“The laureates’ discoveries launched the field of peripheral tolerance, spurring the development of medical treatments for cancer and autoimmune diseases,” the Nobel Assembly said in a news release. “This may also lead to more successful transplantations. Several of these treatments are now undergoing clinical trials.”

Read more: https://apnews.com/article/nobel-prize-medicine-a68cf8a3b930570630168a949d277cde

---

Link to tweet

The Nobel Prize
@NobelPrize
·
Follow
BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance."
Image
5:31 AM · Oct 6, 2025

Article updated.

Original article -

Updated 5:38 AM EDT, October 6, 2025


STOCKHOLM (AP) -- Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi have won the Nobel Prize in medicine for their discoveries concerning peripheral immune tolerance.

The trio will be formally awarded the prize, Officially known as the Nobel Prize in Physiology or Medicine, during a ceremony on Dec. 10.

Peripheral immune tolerance is one way the body helps keep the immune system from getting out of whack and attacking your own tissues instead of foreign invaders.

Monday's announcement took place in Stockholm.

[Buddyzbuddy]

1. Wait, you forgot one. Certainly swallowing bleach or putting a light in the body

has earned something for our tiny handed Felon.

[Ray Bruns]

2. Even though RFK Jr's work in leeches and bloodletting was "groundbreaking"

He was not considered for the prize.

[Buddyzbuddy]

3. In another world if RFK jr. were considered the Felon would scratch his eyes out.

[LudwigPastorius]

4. But, what about Trump?

He cured 7 diseases...cured 'em completely like nobody's ever seen before.

He had big, burly doctors coming up to him with tears in their eyes saying, "Thank you, Sir, for doing what couldn't be done".