"You can't get there from here!"
Have you ever been watching a movie or series made in your hometown, and they show the characters driving along the roads? And then they turn onto a road that does not connect, and end up at a place that's in the exact opposite direction they were going?
I figure this probably is most noticeable to our members that live in Los Angeles and New York City. But sometimes film-makers go into the interior of the country, and we get to see their vision of what traveling to various places is like. That is, a severe lack of geographic continuity 
This past spring I finally watched Paris, Texas by Wim Wenders. Toward the end of the movie (no spoilers here) Harry Dean Stanton's character, Travis, is seen driving away from Houston on Highway 59, too far north to make a west turn onto I-10, yet he does anyway. Then he's turning back south toward the city again, and ends up at a big motor-bank in downtown Houston, when he was supposed to be heading out of town.
The movie is wonderful, yet knowing how the roads truly connect causes me to be interrupted from being immersed in the film. Of course, if you don't live here, or have traveled here, you'll never notice, and the film-maker is counting on that ignorance.
So, what scenes of traveling have caused you to say or think "You can't get there from here!" when watching something? 
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that line always makes me think of a Firesign Theater gag, from Nick Danger. 
"You can't get there from here."
"I'm looking for the same old place."
"Oh, you must mean the old Same Place! It's out back. Here's the key."
Four hours later I parked my car in the carriage house outside the Same mansion. What was it about this place?
~~~
You mean that quote from Nick Danger, Third Eye? 
I loved that bit...just hilarious.
And, tends to get recited by everyone in the room who remembers it.
Someone with more time on their hands than imaginable needs to get a copy of ArcMap and make a GIS map of all the routes taken in movies, color-coded so you can see how disjointed the routes are in reality
That's one of the main buildings on the Simon Fraser University campus where I went for a few years. It's in the FLY II and it's been used a number of times in different TV series.
What about this place?
That's the Vancouver Public Library, also used in a number of movies and TV series.
A LOT of TV is filmed here in Vancouver. If you watched the X-Files, Smallville, Millenium, The 4400, all 3 Stargates, among many others, you will recognize many Vancouver locations.
So yeah I know the feeling
Here's a list of film/TV locations and series names for Vancouver:
http://en.wikipedia.org/wiki/List_of_filming_locations_in_the_Vancouver_area
Not uncommon to see more than one of these locations in a movie or TV series and some completely illogical series of events linking them.
They used them extensively! Nice photos, though. It's interesting to see them without actors in them
I was thinking more about the route someone takes, however they're traveling (car, boat, on foot, bike) and you see them going in directions that are impossible in reality, or would send them in circles when they're being depicted as going in a relatively straight direction
And I know they film in Vancouver because it's supposedly less expensive.
That's my first thought every time I hear a talking in-car GPS.
I'm not nitpicking, either. It's an issue of familiarity. When someone drives in a film where you live or have grown up, and their route is physically impossible, or takes the character in circles, you're going to notice
set in Chicago, with a scene that has several palm trees as a backdrop.