Which incumbent US Senators up for re-election in 2022 will be defeated for re-election?

[nkpolitics1212]

GA(Warnock-D) in the general election runoff on 12/2022.
NH(Hassan-D) if Sununu-R ends up running and becomes the Republican nominee.
WI(Johnson-R) decides to seek re-election.
FL(Rubio-R) vs Demings-D
NV(Cortez Masto-D) vs Laxalt-R
AZ(Kelly-D) vs Brnovich-R
OPEN US Senate seats like to change political parties.
NC(OPEN Burr-R) Beasley-D or Jackson-D
OH(OPEN Portman-R) Ryan-D
PA(OPEN Toomey-R) Fetterman-D
IA(Chuck or Pat Grassley-R) Finkenauer-D

[jimfields33]

1. I think pennsyvania is our best bet in gaining a seat.

Others will as well but pennsyvania is pretty close to guaranteed.