Health
Related: About this forumWhy Getting Healthy Can Seem Worse Than Getting Sick
A new article in The Quarterly Review of Biology helps explain why the immune system often makes us worse while trying to make us well.
snip
The research offers a new perspective on a component of the immune system known as the acute-phase response, a series of systemic changes in blood protein levels, metabolic function, and physiology that sometimes occurs when bacteria, viruses, or other pathogens invade the body. This response puts healthy cells and tissue under serious stress, and is actually the cause of many of the symptoms we associate with being sick.
"The question is why would these harmful components evolve," asks Edmund LeGrand (University of Tennessee, Knoxville), who wrote the paper titled with Joe Alcock (University of New Mexico). The researchers contend that answer becomes clear when we view the acute-phase response in terms of what they call "immune brinksmanship."
The immune brinksmanship model "is the gamble that systemic stressors will harm the pathogens relatively more than the host," LeGrand said. The concept, he explains, is akin to what happens in international trade disputes. When one country places trade sanctions on another, both countries' economies take a hit, but the sanctioning country is betting that its opponent will be hurt more.
"One of our contributions here is to pull together the reasons why pathogens suffer more from systemic stress," LeGrand said.
http://www.sciencedaily.com/releases/2012/03/120320161459.htm
Laelth
(32,017 posts)-Laelth
zipplewrath
(16,646 posts)A more apt metaphor is chemotherapy, where we subject one to poisons, intending to kill the cancer before we kill the host. A fever is roughly the same concept. The body increasing its temperature, at the risk of harming the host, in order to kill an "invader". Fighting fire with fire so to speak.
Warpy
(111,336 posts)in the upper respiratory system in the hope that infected cells are sloughed off before the virus can reproduce. That's what produces the sore throat and dripping nose.
I tend not to treat a fever unless it's over 101.5F because the low grade fever is the body's way of making things uncomfortable for virus replication and it works just fine most of the time.
zipplewrath
(16,646 posts)Wife always asks why I don't "take something" when I have a low fever. My response is usually something along the line of "my body's fighting, why would I want to interfere?"