Has anyone had a dog diagnosed with Ishemic Dermatopathy?

[Bayard]

One of our Great Pyrenees has, by the animal dermatologist. I've been reading up on it. Seems to mostly hit younger and smaller dogs. Nothing about a Pyr. There is a type of it that can be brought on by a reaction to a rabies vaccination. Not what we have here.

They're running one other lab yet to get a definitive diagnosis. Pre-lymphoma is also being mentioned.

Obviously, we are pretty worried. He's 12 yrs old, so we would not put him through chemo. In the past, I've had two other dogs that died from lymphoma.

I'll take his stitches out tomorrow from the biopsy.

Any experience relayed would be much appreciated.

[onecaliberal]

1. Healing vibes...

🙏🏻

[MLAA]

2. Sending love

[SheltieLover]

3. If they are making noises about lymphoma, have pcrs run for ehrylichiosis!

https://ashpublications.org/blood/article/106/11/4343/122950/Ehrlichiosis-Mimicking-T-Cell-Lymphoma-Leukemia

U of IL vet pathology lab us superb in dxing this.



On edit: this is an exrremely complex disease. Takes experts to dx.

Treatment is imizol.

[niyad]

4. No information, but healing vibes on their way.

[Karadeniz]

5. I've heard that dogs handle chemo much better than people do.

[hlthe2b]

6. Psst. Ischemic Dermatopathy

It is accompanied by a loss of blood supply to the affected tissue, thus the term "ischemic."

Treatment exists beyond steroids (glucocorticoids) which have been the mainstay (humans get something somewhat similar). It is an exclusion diagnosis, though, meaning that even with a biopsy there have to be a lot of other conditions excluded before they can definitively conclude.

The studies on this are not great and there is a belief that case series of vaccine associations are greatly overstating an association as the few larger better conducted studies show at least half if not more cases have nothing to do with rabies vaccine. Similar to autoimmune conditions in humans where recent vaccination CAN be associated but rarely. There are as yet unidentified "triggers" including possible recent infection with many organisms including vector-borne disease.

Therapeutic options include pentoxifylline, glucocorticoids, oclacitinib, and/or other immunosuppressive agents (eg, mycophenolate, modified cyclosporine, sulfones, sulfasalazine).

Good luck!

[Bayard]

7. Thank you, my friends

There's some good info posted here.


I have a whole list of questions for the vet when we go back.

[Duppers]

8. I've nothing to add

Except good thoughts for your big puppers.

Please keep us posted.