Key narcolepsy–influenza vaccine findings retracted

[HuckleB]

http://news.sciencemag.org/brain-behavior/2014/07/key-narcolepsy-influenza-vaccine-findings-retracted

"Since swine flu swept the globe in 2009, scientists have scrambled to determine why a small percentage of children in Europe who received the flu vaccine Pandemrix developed narcolepsy, an incurable brain disorder that causes irresistible sleepiness. This week, a promising explanation was dealt a setback when prominent sleep scientist Emmanuel Mignot of Stanford University in Palo Alto, California, and colleagues retracted their influential study reporting a potential link between the H1N1 virus used to make the vaccine and narcolepsy.

Some researchers were taken aback. “This was one of the most important pieces of work on narcolepsy that has come out,” says neuroimmunologist Lawrence Steinman, a close friend and colleague of Mignot’s, who is also at Stanford. The retraction, announced in Science Translational Medicine (STM), “really caught me by surprise,” he says. Others say that journal editors should have detected problems with the study’s methodology.

The work provided the first substantiation of an autoimmune mechanism for narcolepsy, which could explain the Pandemrix side effect, researchers say. The vaccine, used only in Europe, seems to have triggered the disease in roughly one out of 15,000 children who received it. The affected children carried a gene variant for a particular human leukocyte antigen (HLA) type—a molecule that presents foreign proteins to immune cells—considered necessary for developing narcolepsy.

In the 18 December 2013 issue of STM, Mignot and colleagues reported that T cells from people with narcolepsy, but not from healthy controls, are primed to attack by hypocretin, a hormone that regulates wakefulness. They also showed molecular similarities between fragments of the H1N1 virus and the hypocretin molecule and suggested that these fragments might fool the immune system into attacking hypocretin-producing cells.

..."


Perhaps of interest...

[intaglio]

1. This was probably encouraged by the disputed link between Spanish 'Flu

and encephalitis lethargica (the book an film "Awakenings,"

[libodem]

3. That was a great book

I had to keep my Mosby''s medical dictionary close to look up some of the terminology but it helped me understand my Parkinsons patients like nothing else had. My ex developed Lupus after a bout of Fifth's Rash.

[bananas]

2. So we still don't know why the vaccine caused narcolepsy.

Have they at least started screening for the HLA gene before giving kids the vaccine?

[libodem]

4. I was listening to a Dr

Talk about it last night on Coast to Coast. But I think he was saying flu set off the autoimmune attack on what ever organ or gland makes melatonin. It was 3 am and I could not sleep but I didn't listen that we'll either. Sorry I can't be more concrete.