Though inoculation was a worthy step. Thank goodness for the bravery of those who didn't believe disease was god-given and must be suffered.
I believe that the John Adams family decided to inoculate against smallpox when the "clinical trial" (as the article I posted called it) period was in its infancy.
http://www.celebrateboston.com/first/inoculation.htm(didn't mean to hijack over to inoculations but there were some very brave guinea pigs that paved the way for vaccine and other ways to prevent disease)