Reply #124: Stanford, AIDS.org, Dr. Steve Harris... fyi [View All]

[HysteryDiagnosis]

http://www.aids.org/atn/a-352-02.html
NAC and Glutathione: Recent Publications


by John S. James
Published: October 6, 2000
We were surprised to learn how much work has been published recently on glutathione blood level, oxidative stress, and/or NAC or similar treatments to correct abnormally low glutathione, in various illnesses including HIV infection. Here are some of the papers that have been published in 1998, 1999, and 2000, listed alphabetically by first author. Quotes are from the authors' abstracts; comments in brackets are ours.

We collected these references so that researchers and physicians can quickly see how much new information exists. NAC should no longer be relegated only to "alternative" treatments, but deserves serious research as a possible addition to mainstream HIV therapy.

Clinical papers: http://www.aids.org/atn/a-352-02.html



http://www.aids.org/atn/a-266-01.html

Stanford NAC Study: Glutathione Level Predicts Survival


by John S. James
Published: March 7, 1997
A small randomized controlled trial of oral N-acetylcysteine(NAC) -- organized primarily by Drs. Leonard and Leonore Herzenberg, both Ph.D., at Stanford University, and designed by them and Greg Dubs, Ph.D., who conducted the trial -- was run in San Francisco in 1993 and 1994. A report from this study was published this week in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA(1); it was also presented at a major immunology conference in San Francisco on February 22, receiving television and newspaper coverage. The basic findings were:

(1) For persons with a CD4 count under 200, an abnormally low level of glutathione -- inside CD4 T-cells in the blood --was remarkably predictive of poor survival. (Glutathione is the major defense of those cells against oxidative stress.) Persons with a CD4 count under 200, who also had very low glutathione levels, had an estimated three-year survival a slow as 20 percent -- compared to 60 to 80 percent survival for those with CD4 below 200 but with adequate glutathione levels. (Survival results were presented for those with CD4 counts under 200, since in the three years after the blood measurement, there were not enough deaths to analyze in those with counts above 200. However, the survival difference was also statistically significant when everyone was included regardless of CD4 count.)


http://yarchive.net/med/glutathione.html

From: [e-mail](Steven B. Harris)
Subject: Re: GSH Deficiency!!
Date: 16 Mar 1997
Newsgroups: misc.health.aids

In <[e-mail]> Kevin <[e-mail]> writes:

>Latest findings indicate that Glutathione (a tripeptide amino acid
>composed of glycine, cysteine, and glutamic acid) deficiencies, are a
>good marker of AIDS disease progression. Not surprisingly, Glutathione
>deficiencies are common in people who consume alcohol, tobacco and
>certain drugs.


The "certain drugs," are mostly things that contain Tylenol-- not
exactly known or suspected of causing AIDS. Otherwise your grandma
would have it. You're being guilty of Duesbergian vagueness here.

For the record, glutathione deficiency is a marker for nearly any
condition of poor nutrition, poor health, and chronic inflammation.
It's pretty nonspecific, and doesn't mean a lot. It's sort of like
having pale skin and ratty looking hair.

Steve Harris, M.D.