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JI7 Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 05:34 AM
Original message
Skin Cancers Triple Among Those Under 40
<The incidence of two forms of skin cancer has tripled among people under 40 — particularly women — an increase scientists attribute to tanning's continued allure and Earth's diminishing ozone layer.

Researchers from the Mayo Clinic in Minnesota say rates of basal and squamous cell carcinomas have risen dramatically over the last quarter century, despite repeated public health messages about the importance of sunscreen and protective clothing. The two cancers normally are seen in people over 50. On rare occasions, doctors said Tuesday, the cancers have been diagnosed in teens and preteens.

"This has been evolving over time, and it has just gotten to the point where it has hit our radar screen," said Dr. Leslie Christenson, a dermatologic surgeon at the Mayo Clinic whose study is reported in the current issue of the Journal of the American Medical Assn. "Parents are good about putting sunscreen on children but as children reach their adolescent years, parents are no longer allowed to do that."

She and her team examined the health records of 500 people living in Olmsted County, Minn. She said the population was mostly white and was representative of most white populations throughout the country. As a result, the findings can be extrapolated to people living elsewhere.

The two malignancies, most common among people with fair complexions and red or blond hair, differ in terms of how they look and grow. Both develop on the skin's surface and tend not to spread to distant parts of the body as would melanoma, their deadlier cousin. However, if left untreated, squamous cell carcinoma can invade deeper and metastasize.>

http://www.latimes.com/features/health/women/la-na-skincancer10aug10,1,2647030.story?coll=la-health-womens
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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 05:56 AM
Response to Original message
1. They are starting to put green tea extract and other cancer stopping
antioxidants such as lipoic acid, vitamin c, pycnogenol etc in topical skin creams. These creams (to me at least) make sunscreen look like kids stuff.

Google for green tea cream.

1: Waleh NS, Chao WR, Bensari A, Zaveri NT. Related Articles, Links
Novel D-ring analog of epigallocatechin-3-gallate inhibits tumor growth and VEGF expression in breast carcinoma cells.
Anticancer Res. 2005 Jan-Feb;25(1A):397-402.
PMID: 15816564

2: Hsu S, Farrey K, Wataha J, Lewis J, Borke J, Singh B, Qin H, Lapp C, Lapp D, Nguyen T, Schuster G. Related Articles, Links
Role of p21WAF1 in green tea polyphenol-induced growth arrest and apoptosis of oral carcinoma cells.
Anticancer Res. 2005 Jan-Feb;25(1A):63-7.
PMID: 15816520

3: Horie N, Hirabayashi N, Takahashi Y, Miyauchi Y, Taguchi H, Takeishi K. Related Articles, Links
Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells.
Biol Pharm Bull. 2005 Apr;28(4):574-9.
PMID: 15802789

4: Yang CS, Liao J, Yang GY, Lu G. Related Articles, Links
Inhibition of lung tumorigenesis by tea.
Exp Lung Res. 2005 Jan-Feb;31(1):135-44.
PMID: 15765923

5: Hastak K, Agarwal MK, Mukhtar H, Agarwal ML. Related Articles, Links
Ablation of either p21 or Bax prevents p53-dependent apoptosis induced by green tea polyphenol epigallocatechin-3-gallate.
FASEB J. 2005 May;19(7):789-91. Epub 2005 Mar 11.
PMID: 15764647

6: Baliga MS, Meleth S, Katiyar SK. Related Articles, Links
Growth inhibitory and antimetastatic effect of green tea polyphenols on metastasis-specific mouse mammary carcinoma 4T1 cells in vitro and in vivo systems.
Clin Cancer Res. 2005 Mar 1;11(5):1918-27.
PMID: 15756018

7: Chueh PJ, Wu LY, Morre DM, Morre DJ. Related Articles, Links
tNOX is both necessary and sufficient as a cellular target for the anticancer actions of capsaicin and the green tea catechin (-)-epigallocatechin-3-gallate.
Biofactors. 2004;20(4):235-49.
PMID: 15706060

8: Qanungo S, Das M, Haldar S, Basu A. Related Articles, Links
Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cells.
Carcinogenesis. 2005 May;26(5):958-67. Epub 2005 Feb 10.
PMID: 15705601

9: Babich H, Krupka ME, Nissim HA, Zuckerbraun HL. Related Articles, Links
Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity.
Toxicol In Vitro. 2005 Mar;19(2):231-42.
PMID: 15649637

10: Yang SP, Raner GM. Related Articles, Links
Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract.
Toxicol Appl Pharmacol. 2005 Jan 15;202(2):140-50.
PMID: 15629189

11: Zhou YD, Kim YP, Li XC, Baerson SR, Agarwal AK, Hodges TW, Ferreira D, Nagle DG. Related Articles, Links
Hypoxia-inducible factor-1 activation by (-)-epicatechin gallate: potential adverse effects of cancer chemoprevention with high-dose green tea extracts.
J Nat Prod. 2004 Dec;67(12):2063-9.
PMID: 15620252

12: Adhami VM, Siddiqui IA, Ahmad N, Gupta S, Mukhtar H. Related Articles, Links
Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer.
Cancer Res. 2004 Dec 1;64(23):8715-22.
PMID: 15574782
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bananas Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 06:25 AM
Response to Reply #1
2. Can you recommend any products?
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HysteryDiagnosis Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 06:50 PM
Response to Reply #2
20. Unfortunately.... it is not allowed. Sorry. However, if you goto
www.lef.org you will be able to find articles that "may" help you out.
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izzie Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 06:28 AM
Response to Original message
3. I hate to say LOOK at the people who have lived in hot countries
They cover up from the sun. Hot part of the day they stay indoors and rest. They cover them selfs with covers that do not grab the body and they wear something on their heads. Frankly just as a lady of 70 had to dress as a child who spent the summers at the beach. We were always under cover but for going into the water. I also went through the 'tan' thing but got over it once I saw the 'Winter' people from the South in Maine in the summer and saw their skin. It looked like my wallet. I know I sound like I am from the time zone but I figure after 7000 years the Middle East knows more about hot weather than we do.:think:
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Nihil Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 10:39 AM
Response to Reply #3
15. Ding! Ding! Ding! You are RRRIIIIGGGHHHTTT!
> Hot part of the day they stay indoors and rest.

> They cover themselves with covers that do not grab the body

> they wear something on their heads.

These three things alone will solve most of the "Western" issues with
skin cancer.

If you want to add a fourth: don't use sunscreen as often - just avoid
the sun.

The "scientifically marketed" crap that people have been encouraged to
smear all over for every hour of the day contributes to the damage both
directly (chemical cocktails) and indirectly (false sense of security
leading to over-exposure).
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TX-RAT Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 11:10 AM
Response to Reply #3
17. Thats the way it is in West Tx
You wear a hat.
Long sleeves
Long pants.
And stay out of the sun if possible.
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sendero Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 06:36 AM
Response to Original message
4. I have to wonder...
.... if this doesn't have more to do with the ozone layer or other environmental factors than it does with increased sun exposure.

It seems like skin cancer keeps increasing even as there is more and more awareness of the dangers of sun exposure. I just think it is a lot more complicated than more sun.
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wishlist Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 06:53 AM
Response to Reply #4
6. Wonder if less ozone is involved, since sunscreens should be helping
As a babyboomer who grew up in the northern U.S. and suffered from sunburns as did most of my family and friends. I don't recall seeing or hearing about sunscreen lotions that prevented sunburn until the 1970's.
We were outside more back then in the 1950's and 60's due to not much on TV and no computers or air conditioning and as kids we worked on farms more back then too.

So it seems strange to me that it would be the younger generation who tend to be indoors more with ready access to sunscreen who are getting more skin cancer.
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mcscajun Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 07:01 AM
Response to Reply #6
8. Don't wonder...read...
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SheepyMcSheepster Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 08:02 AM
Response to Reply #8
11. thanks
that's a disturbing article.
these people may be experiencing what the future is like for the rest of us.
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mcscajun Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 08:24 AM
Response to Reply #11
13. Exactly. So disturbing that I haven't forgotten it since I read it...
...and Punta Arenas, a place I'd never heard of, is the first thing I think of when this topic comes up.
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H5N1 Donating Member (777 posts) Send PM | Profile | Ignore Wed Aug-10-05 11:32 AM
Response to Reply #8
19. whoa...
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mcscajun Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 07:01 AM
Response to Reply #4
7. Don't need to wonder....read...
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Sgent Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 06:46 AM
Response to Original message
5. My vote
1) The migration of people southward (Flordia, Arizona, Atlanta, etc.)
2) The prevalence of tanning beds, home tanning beds, etc. And the fact that many people use them for much longer than previously.
3) The prevalence of low latitude vacationing. 2 hrs of laying out in Cancun or Flordia is gonna do more damage than a whole summer at the hamptons. (exageration, but you get the point).
4) In cities, a lot of excess ozone (pollution) which intenifies the sun.

Last would be ozone thining IMHO. But it could be having an effect not otherwise seen.
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mcscajun Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 07:02 AM
Response to Reply #5
9. Before you vote....read...
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noonwitch Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 07:49 AM
Response to Original message
10. I don't purposely lay in the sun or anything
I have a little more color in the summer than the rest of the year, but I never try to get a tan or anything. If I'm going to be out in the sun for long, I wear sun block and a hat.

I don't think the hole in the ozone is the factor that alone has caused the increase in skin cancer. I have to be careful about the sun, because I have red hair and very pale skin. Many people with darker skin think they are safe if they don't get burned, and that's just not true. So, they take risks that they probably shouldn't take, especially young females, who will do anything if they think it will make them prettier.
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HuckleB Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 08:09 AM
Response to Original message
12. Is it an increase in cancers or in screening?
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jus_the_facts Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 08:30 AM
Response to Original message
14. TANNING BEDS are another major factor...people don't realize...
...they are literally BAKING themselves in them...several layers deep in fact. x(
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shanti Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 10:52 AM
Response to Original message
16. i can attest to this
grew up in southern california, light skin (can tan lightly), hair, and eyes. had a couple of serious, blistering sunburns in my teens. i haven't sunbathed since my early twenties and i am now 49. i had a basal cell carcinoma removed from my cheek about 3 years ago.

the dangers are very real!!
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donsu Donating Member (1000+ posts) Send PM | Profile | Ignore Wed Aug-10-05 11:26 AM
Response to Original message
18. and all those boyscouts in the sun without hats or sunglasses for hrs.


I think whoever was in charge of the scouts should be fired. they didn't think of the boys first.
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