Pharmaceuticals in the Water: A Perfect Storm? Green Chemistry
This week, the Second International Symposium on Green Processing in the Pharmaceutical and Fine Chemical Industries was held at Yale University in New Haven. The event brought together some of the finest minds working in green chemistry today, from industry, academia and government.
Discussing the problem were Peterson Myers, CEO at Environmental Health Sciences and coauthor of "Our Stolen Future," Nicholas Anastas, a scientist from Massachusetts DEP, and Duane Huggett from the University of North Texas' Institute of Applied Sciences.
Several attendees noted that some drug companies, notably Pfizer, AstraZeneca and Merck, have already come up with detailed databases and that this work is ongoing. (Yes, but it's also voluntary...and we cynics know what can happen with voluntary industry programs that aren't universally embraced) Concerns were aired that this may ultimately prove to be a "non-issue," and wouldn't it be a shame if overly prescriptive measures were taken. Panelists also discussed new ways of analyzing impacts that could form the basis of future regulations.
Looming Water Shortages and the "Tamoxifen Effect"
Mr. Myers sees the issue becoming "a perfect storm" for the industry, driven by global water shortages and the fact that "21st century endocrinology is beginning to replace 16th-century toxicology" as the method for gauging impact. "It won't go away," ne noted. As Nicholas Anastas later asked, channeling Rumi, "Do you
want to be the moth or the flame?" (He was asking the wrong crowd, though. These were scientists, who generally pursue the truth, however unpalatable it may be. Perhaps the question should be directed to the C-level at top executive meetings.)He then mentioned non-monotonic dose response curves, and what some studies have seen with Tamoxifen, the breast cancer drug. At the right concentration levels, the drug can destroy cancer cells, but at lower concentrations, some studies have found that it may stimulate the growth of tumors! "The regulatory system is blind to this type of effect," he said. "And we may find that some pharmaceuticals in our drinking water follow these same curves."
Mr. Hugget from Texas noted the strains on Dallas' water system, and the Trinity River which, at one point is 90% effluent. Given that the local population is expected to double by 2050, people will eventually have to use recycled water. He also mentioned a recent Warsaw meeting in which 89 presentations focused on pharmaceuticals in the environment, as well as the data from India, published in Chemical Week and C&EN, which found extremely high levels of drugs in manufacturing effluents.
http://community.pharmamanufacturing.com/content/pharmaceuticals-water-perfect-storm-green-chemistry-event-opens-discussion
The chemical/drug companies they know what is happening to our water...