Reply #16: PhD input, link, excellent explanation..... [View All]

[HysteryDiagnosis]

http://neuro-www.mgh.harvard.edu/forum/HuntingtonsDiseaseF/HDTreatment.GeneExpression.htm


Ronald B. Keys, JD, PhD wrote:
>
A CLINICAL CONTEXT FOR TREATMENT OF FRIEDREICH'S ATAXIA

Dear PATIENT XXXXXX,

Clinical toxicology refers to clinical evaluation and clinical context of the science that treats of the origin, nature, properties and effects of poisons, of their detection in the organs or tissues, of their antidotes, and of the treatment of diseases due to poisoning. The failure of your cytochrome P-450 phase I detox system is toxicogenic or tending to produce poisons internally.

A toxin is any toxic matter generated in living or dead organisms or any of a class of more or less unstable poisonous compounds elaborated by animal, vegetable or bacterial organisms and acting as causative agents in many diseases. usually after an incubation period. The toxins, in your case, are EXCESSIVE FREE RADICAL MEDIATED/INDUCED that over-accumulate in nervous and muscle tissue, leading to wasting and destruction of that tissue.

Simply and elegantly put, you are being progressively poisoned to death. Free radicals also know as REACTIVE OXYGEN SPECIES, when produced in excess, become POISONS to the maintainance, function and integrity of living tissue.

In free radical biology and medicine, when the net accumulation of free radicals or random oxygen species (ROS) occurs faster than their rate of removal at specific sites, tissue damage occurs with compromise in cell, tissue and organ function. But, it is normal in all tissues for ROS to be involved as free radical storms or cascades to break down normal tissue so thet it may be replaced, as part of positive nitrogen balances in anabolism; the single and double strand replacements of polypeptide chains are involvied in normal, day to day protein synthesis and cellular repair following ROS damage.

It must first have a mechanism to break down tissues in order to build the tissues and its systems back up. ROS release and damage is part of that normal process. Free radical activity is a necessary part of all growth and repair processes in human metabolism because all tissues have to be broken down first in order to be repaired later. In degenerative or catabolic states, called CATABOLISM, involving negative nitrogen balances and protein wasting, there is excessive release of ROS or mounting free radical bursts in tissues that waste instead of serving as a basis for later repair of that same tissue.

When this happens, the free radical bursts with ROS release, become POISON RELEASERS with each separate free radical at that point becoming a POISON.