cardiac implications. People using it need to be monitored for signs of cardiac instability and the pharmy needs to monitor what other drugs a patient is taking to watch for interactions.
Cardiac problems and drug interactions are very, very unlikely for inhaled albuterol at the recommended doses. It's a
selective beta-2 agonist, and its general lack of cardiac effects is why it replaced the older, non-selective bronchodilators such as the "proterenol" series.
As it happens, the OTC inhalers are good ol' epinephrine, which is about as nonselective as you can get, affecting not just beta-2 receptors, but beta-1 and alpha receptors as well. Epinephrine is a direct cardiac stimulant, and Primatene Mist could theoretically cause problems for someone with an underlying heart condition.
I'll hasten to add that I'm not bashing Primatene. I'm glad it's available. It's helped me out on numerous occasions. For the uninsured, it's usually the only game in town. But apart from emergency treatment of anaphylaxis (in which epinephrine, not albuterol, is the standard rescue therapy)*, albuterol is generally a much better choice for rescue inhalers. And I think that everyone who needs it should have unimpeded access to it.
Let's face it. We have a LOT of uninsured and underinsured people in this country. And a lot of them have chronic medical conditions that they are forced manage all by themselves, as best they can. Too many safe, useful medicines have been put completely out of their reach with little or no real justification.
*A person lacking access to an Epipen or other epinephrine injection might
possibly have better luck surviving long enough to get to the hospital if they have inhalable epinephrine handy. This is not really recommended, except perhaps on the 'better-than-nothing' principle.