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SorellaLaBefana

SorellaLaBefana's Journal
SorellaLaBefana's Journal
July 17, 2025

Coming soon to USA?: "Armed police threatened to arrest Kent protester for holding Palestinian flag"

Armed police threatened a peaceful protester with arrest under the Terrorism Act for holding a Palestinian flag and having signs saying “Free Gaza” and “Israel is committing genocide”, accusing her of supporting a proscribed organisation.

Officers told Laura Murton, 42, that her demonstration in Canterbury, Kent, on Monday evening expressed views supportive of Palestine Action, which was banned under terrorism legislation earlier this month...

He went on to say that the phrase “Free Gaza” was “supportive of Palestine Action”, adding it was an offence “to express an opinion or belief that is supportive of a proscribed organisation, namely Palestine Action is an offence under section 12(1A) of the Terrorism Act”. The officer told her she had committed that offence...

Tom Southerden, Amnesty International UK’s law and human rights director, described the footage as “very concerning”. He added: “We have long criticised UK terrorism law for being excessively broad and vaguely worded and a threat to freedom of expression. This video documents one aspect of exactly the kind of thing we were warning about.”

https://www.theguardian.com/world/2025/jul/17/armed-police-threatened-to-arrest-kent-protester-for-holding-palestinian-flag

Think about this. Yes. Apparently mentioning anything which might possibly be construed as aligning with a "proscribed terrorist organisation"—is enough to charge a person with terrorism.

To say, for example, that children in Gaza are dying because of the actions of I-dare-not-speak-the-name so will only say "another Middle Eastern" nation can land you in prison.

Golly, that's not scary at all.
July 11, 2025

Should Adults in ICU have gene testing? Recent study (possibly) suggests YES

Genetic testing of critically ill adults can yield surprises—and reveal disparities in treatment of Black patients
...Nearly one-quarter of the adult patients had genetic diagnoses pertinent to their symptoms in the ICU, the researchers found—and half of those people had not previously been aware of these genetic disorders. The team also found Black patients were far less likely than white patients to receive these personalized diagnoses before or during their ICU stay...

The study found similar rates of genetic diagnoses among younger and older patients, which challenges the prevailing dogma among disease geneticists...

moz-extension://a6e7ca96-1bf5-45d7-9d20-b41077fe566f/data/reader/index.html?id=20&url=https%3A%2F%2Fwww.science.org%2f Content%2f Article%2Fgenetic-testing-critically-ill-adults-can-yield-surprises-and-reveal-disparities

Trying the above link from DU get error. The Science newspiece has doi: 10.1126/science.zlo6ntr


This is a small (365) single-center study of ICU patients between the ages of 18-40. The above report in Science Newsletter does not given any specific examples of what these potentially relevant genetic conditions might be. Intriguing findings.

The study itself is *supposedly* Open Access (Free), however, unless one is a geneticist, it is pretty obscure as to 'what' were the conditions identified expressed in even clinically understandable terms, much less for the lay person. Won't bother to quote the jargon. Nice graphic at the start



The clearest statement I could find was that "Cardiac, vascular, and malignancy-associated genes predominate..." The Discussion segment says
The results of this study investigating genomic sequencing in the critically ill adult population serve as a pivotal advancement in our understanding of the impact of monogenic disease on adults. Nearly 25% of all UPHS ICU-admitted patients aged 18–40 years have a Mendelian genetic diagnosis related to their ICU admission. For over 75% of these patients, their genetic diagnosis confers specific care-altering management recommendations. The implication here is profound: the clinical benefits of broad genomic testing in critically ill adults are greatly underrecognized, and the implementation of exclusion-based genomic testing in this population could dramatically transform patient care and outcomes.

Our findings challenge the dogma that the likelihood of uncovering actionable genetic diagnoses decreases with increasing age.35 Our diagnostic rate of 24.4% is consistent with similar studies in the critically ill neonatal and pediatric populations (diagnostic yields: 21%–38%),2,3,4,9,10 suggesting that critical illness is a strong predictor of Mendelian disease across the lifespan...

In conclusion, the evidence for the utility of broad, exclusion-based exome or genome sequencing in critically ill adults is compelling, with new diagnoses and potential management changes identified in more than 10% of all adult patients aged 18–40 years admitted to any ICU. As precision medicine continues to revolutionize healthcare delivery, it is incumbent upon us to not only recognize the importance of Mendelian genetic disease in adult morbidity and mortality but also to actively incorporate this knowledge into routine clinical practice to alleviate healthcare disparities and improve healthcare outcomes across the board.

https://www.cell.com/ajhg/fulltext/S0002-9297(25)00238-1

Humm. For some reason when trying the above link from DU get "an error has occurred". The Citation export from the article is

Exclusion-based exome sequencing in critically ill adults 18–40 years old has a 24% diagnostic rate and finds racial disparities in access to genetic testing
Gold, Jessica I.Mansfield, Adam J.PoindeTxter, Afiya et al.
The American Journal of Human Genetics, Volume 0, Issue 0

"Volume 0, Issue 0" makes one a bit suspicious. There is no DOI. The American Journal of Human Genetics is a long standing and (at least formerly) valid journal established in the middle of the last century. No idea of what the problem may be.

Thought this would be an interesting, QUICK post!?


Frankly, although the "Conclusion" (vide supra) reads, to me, more like a financial prospectus than a scientific conclusion there may be clinical value in such testing.

However, the challenges facing our healthcare industry (it cannot be called a system) are of less speculative and of more immediate import: Access; Public Heath Measures and Science Based practices
July 9, 2025

How much energy do fish expend when floating "effortlessly" in the water column?


Turns out to be twice their requirement at rest

Fish make hanging motionless in the water column look effortless, and scientists had long assumed that this meant it was a type of rest. Now, a new study reveals that fish use nearly twice as much energy when hovering in place compared to resting...

...In particular, the scientists measured the physical separation between the fish's center of mass, which is determined by weight distribution, and its center of buoyancy, which is related to the shape and location of its swim bladder. All these measurements provided a way to quantify how stable or unstable each fish was...

"Hovering is a bit like trying to balance on a bicycle that's not moving," said Di Santo...

https://www.sciencedaily.com/releases/2025/07/250708045658.htm

The image used in the Science Daily article is of the Garibaldi Fish. This is the largest of the damselfish, and lives in Kelp Forests off the California coast. As divers know, such forests slow, but do not eliminate, currents so the fish pictured are likely also slowly swimming into the current besides hovering—as well as keeping an eye on the photographer!

The Monterey Bay Aquarium has a nice family-friendly discussion of the fish:
https://www.montereybayaquarium.org/animals/animals-a-to-z/garibaldi



July 4, 2025

Sharecroppers Revolt: Vorst's 1939 painting for the WPA


In the heady 1960s never did I think to see such disparity again for we were becoming a more just, a more kind and a more inclusive society.

"Jesus wept" (John 11:35)

Jesus wept, for Jesus had compassion. He wept even though He knew He would soon fix the cause for weeping.

Sadly, unlike Jesus raising the four-day dead Lazarus, no one is coming to raise our dying democracy—no one except those who do not prostrate themselves before the cruel, cowardly and heartless thugs who have seized our government.

Benjamin Franklin’s reply of “A Republic, if you can keep it.” to the question of “…what have we got, a republic or a monarchy?” has not been in such doubt for a very long time.

Happy Fourth of July
July 2, 2025

Brilinta, Big Pharma, Corporate Greed and the FDA

The British Medical Journal reports that Brilinta (ticagrelor)—a drug used to treat people having a heart attack—might have been approved for use over equally effective, cheaper and safer drugs because of data manipulation and flawed (yes, let’s just say *flawed*) FDA review. In the following excerpt, bolding has been added as well as comments [in brackets]

Fresh concerns have emerged about the platelet studies underpinning the FDA approval of ticagrelor, AstraZeneca's multibillion-dollar heart drug. A new BMJ investigation reveals data discrepancies, missing lab readings, and questions about the integrity of the trial process. Notably, key results reported in a major cardiology journal were inaccurately presented, and some study contributors were omitted or denied involvement. With generics on the horizon, critics say these revelations highlight potential dangers, including severe rebound effects and bleeding risks, that were never properly disclosed

It finds that the "primary endpoint" results (the trial's key measurement) for both clinical trials were inaccurately reported in the leading cardiology journal Circulation, and reveals that more than 60 of 282 readings from platelet machines used in the trials were not present in US Food and Drug Administration (FDA) datasets.

What's more, one active trial investigator never became a study author, while one author told The BMJ he was not involved in the trial, and most investigators, including the principal investigator, were unreachable or declined to be interviewed.

Victor Serebruany, an adjunct faculty member at Johns Hopkins University and ticagrelor's most renowned critic, told The BMJ that "there are episodes of skyrocketing rebound and profound platelet inhibition after ticagrelor making patients prone to thrombosis or bleeding. If doctors had known what happened in these trials, they would never have started using ticagrelor."...

https://www.sciencedaily.com/releases/2025/06/250621233811.htm

This might remind you of the controversial approval of an Alzheimer’s Drug (Aduhelm) in 2021?

Three experts have now resigned from a Food and Drug Administration advisory committee after the agency approved an Alzheimer's drug called Aduhelm [monoclonal anti-beta-amyloid antibody] against the wishes of nearly every member on the panel [since Phase-3 trials gave conflicting and unclear results]…

"Accelerated Approval is not supposed to be the backup that you use when your clinical trial data are not good enough for regular approval," Kesselheim said via Twitter on Monday as the FDA issued its OK for Aduhelm…

The drug will be administered through infusions every four weeks, resulting in a yearly cost of about $56,000, the companies said. That's the list price, which doesn't necessarily reflect the out-of-pocket costs for someone who has insurance and/or Medicare. Preliminary estimates suggest patients' copayments for the drug could cost around $11,500 annually.,,,

https://www.npr.org/2021/06/11/1005567149/3-experts-have-resigned-from-an-fda-committee-over-alzheimers-drug-approval...

Subsequently, Aduhelm was withdrawn from the market in 2024. Apparently cost, unaddressed concerns about brain bleeding and the requirement that a confirmatory trial be undertaken to demonstrate effectiveness made it a poor seller—or, as Biogen put it, simply to "reprioritize its resources" to a newer Alzheimer's monoclonal antibody (Leqembi) that costs only about $26k/year.

Of course, then there is the whole issue of whether or not there is a causative relationship between amyloid plaques and Alzheimer's. That, however, is a story for another day.
July 1, 2025

Rainshadows


Cloud Appreciation Society's Cloud-o-the-Day for 01July25
https://cloudappreciationsociety.org/tuesday-1st-july-2025/

Peace
July 1, 2025

Evocative pix of winner of Tour de France bicycle race

Whilst avoiding new news, came across this news article about the winner of the first Tour de France in 1903

The race was 1,509 miles long! He won by ~3 hours. Those tires look so very fragile.

Assume that the race must currently/soon be being run? Wonder if is still that long. Oh, and he—Maurice Garin—bought a gas-station with his winnings which supported him for the rest of his life. A Happy Ending!

Love his performance enhancing cigarette and jaunty chapeau 

Read more on the Good News Network site:
https://www.goodnewsnetwork.org/events060701/



June 23, 2025

Wind, Migrating Birds and Ultralights (Wonderful 5min YT Vid)

Today I came across this magical video on YT which is from seven years ago. It is *not* AI.


For some reason this immediately reminded me of the (unrelated to the video) studies I read in the past of the Bar-Headed Geese who migrate over the Himalaya mountains. Apparently the mountains arose after the migration patterns were established, and they just continued on that ancestral route flying a bit higher each time!

They found a way forward



The geese now must reach altitudes between 16 to 20 thousand feet. One was documented at almost 24,000 feet. They air is quite thin at those altitudes, geese are not small and oxygen demand is great!

This article discusses the behavioral and physiological adaptations which allow such flights:
https://pmc.ncbi.nlm.nih.gov/articles/PMC4346704/

----
NB: I went to the French site linked to in the YT video. It was blocked by Web of Trust. So went no further. Your mileage may vary, I’m just overly cautious these days when visiting new sites
June 14, 2025

Charming Fox Family in Austin (Wonderful 5min edited YT Video)


This clip is "Gray Fox Zoomies" and shows a fox family playing. The gray fox (Urocyon cinereoargenteus) is the only fox which can climb trees. They are *very* good at it!

"Texas Backyard Wildlife" is made by a couple up in Austin Texas: https://www.youtube.com/@TexasBackyardWildlife

We've followed their YT channel for a long time. Recently, they've been posting less and we were so happy when they started posting again a few weeks ago.
June 12, 2025

Gopher DayTrip to Mt St Helens 2 years after the eruption shows benefits 4 Decades later ⨀ᴥ⨀


Image: https://www.wta.org/news/magazine/features/mount-st-helens-2014-40-years-after-the-blast

When Mount St. Helens erupted in 1980, lava, ash, and debris left the landscape barren for miles. It was obvious that recovery would take decades. But one team of scientists had an unconventional idea to help jumpstart the process: send a few gophers on a one-day mission to the mountain...

"With the exception of a few weeds, there is no way most plant roots are efficient enough to get all the nutrients and water they need by themselves ... The fungi transport these things to the plant and get carbon they need for their own growth in exchange."...

Two years after the eruption of Mount St Helens, local gophers were sent to the area in what must have been quite a confusing day trip, even if the animals were not aware of the news. The gophers were placed in enclosed areas for the experiment and spent their day digging around in the pumice.

Despite only spending one day in the area, the impact they had was remarkable. Six years after their trip, there were over 40,000 plants thriving where the gophers had gotten to work, while the surrounding land remained, for the most part, barren. Studying the area over 40 years later, the team found they had left one hell of a legacy...

https://www.iflscience.com/scientists-dropped-gophers-on-mount-st-helens-for-24-hours-four-decades-later-the-impact-is-astonishing-79573



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